摘要
选择性5-羟色胺再摄取抑制剂类抗抑郁药(SSRIs)是目前临床中抑郁症和焦虑症的一线治疗药物,处方数据显示育龄男性SSRIs类抗抑郁药的使用率不断上升。然而,人们更多关注女性围生期使用此类药物的安全性,忽视对男性患者精液质量及生育能力的影响;而现有的基础和临床研究证据均提示育龄男性长期使用SSRIs类抗抑郁药对其精液参数及生育能力均可产生不利影响。现对相关研究进行系统综述,以期为指导临床用药提供依据。
Selective serotonin reuptake inhibitor(SSRIs)is currently the first-line clinical treatment for depression and anxiety disorders.Prescription data show that the use of SSRIs antidepressants in men of reproductive age is increasing.However,people pay more attention to the safety of perinatal use of SSRIs in women,ignoring the impact on semen quality and fertility in male patients.The available evidence from both basic and clinical studies suggests that long-term use of SSRIs in men of reproductive age can have adverse effects on semen parameters and fertility.Now,a systematic review of relevant studies is presented to provide a basis for guiding clinical use.
作者
王瀚
付冰冰
吕楠
赵茜
张玲
Wang Han;Fu Bingbing;Lyu Nan;Zhao Qian;Zhang Ling(The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;The Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)
出处
《神经疾病与精神卫生》
2022年第3期189-193,共5页
Journal of Neuroscience and Mental Health
基金
北京市医院管理中心临床医学发展专项“扬帆”计划临床技术创新项目(XMLX202128)。
