摘要
目的:探究高通量血液透析联合厄贝沙坦对尿毒症患者的治疗效果。方法:选取2018年5月-2021年5月江南大学附属医院门诊收治的尿毒症患者106例,按照随机数字表法分为对照治疗组和联合治疗组,各53例。对照治疗组采用高通量血液透析治疗,联合治疗组采用高通量血液透析联合厄贝沙坦治疗,采用贝克曼库尔特Power Express全实验室自动化生化免疫流水线检测甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)水平,采用超声心动图检测左心室舒张末期容积(LVEDD)、左心室后壁厚度(LVPWT)、室间隔厚度(IVST)水平,采用酶法检测肾功能指标尿素氮、尿酸、血肌酐水平,采用双抗体一步夹心法酶联免疫吸附试验(ELISA)检测超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、碱性磷酸酶(AKP)、血清转铁蛋白受体(sTfR)、甲状旁腺激素(PTH)水平,采用EGTA络合滴定法检测钙(Ca)水平,采用ELISA双抗体夹心法检测β_(2)-微球蛋白(β_(2)-MG)水平,并统计治疗效果及不良反应。结果:与对照治疗组相比,联合治疗组TG、LDL、LVEDD、IVST、LVPWT、hs-CRP、IL-6、TNF-α、AKP、Ca、PTH、β_(2)-MG、sTfR水平显著低,HDL水平显著高,差异均有统计学意义(P<0.05)。与对照治疗组相比,联合治疗组治疗总有效率较高,差异有统计学意义(P<0.05)。结论:高通量血液透析联合厄贝沙坦能够有效改善尿毒症患者肾功能,显著恢复患者心功能,改善患者血脂水平,减轻患者机体炎症反应,改善Ca、β_(2)-MG等指标水平,其治疗效果显著。
Objective:To investigate the therapeutic effect of high-throughput hemodialysis combined with Irbesartan in uremia patients.Method:A total of 106 patients with uremia who were admitted to the outpatient clinic of the Affiliated Hospital of Jiangnan University from May 2018 to May 2021 were selected and divided into the control treatment group and the combined treatment group according to the random number table method,with 53 cases in each.The control treatment group was treated with high-flux hemodialysis,the combined treatment group was treated with high-flux hemodialysis combined with Irbesartan,and the Beckman Coulter Power Express full-laboratory automated biochemical immune pipeline was used to detect triglyceride(TG),high-density lipoprotein cholesterol(HDL),low-density lipoprotein cholesterol(LDL)levels,and left ventricular end-diastolic volume(LVEDD),left ventricular posterior wall thickness(LVPWT),and inter ventricular septal thickness(IVST)levels by echocardiography,the renal function indicators such as urea nitrogen,uric acid,and serum creatinine levels were detected by enzymatic method,and high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),alkaline phosphatase(AKP),serotransferrin receptor(sTfR),parathyroid hormone(PTH)levels were detected by double-antibody one-step sandwich enzyme-linked immunosorbent assay(ELISA),EGTA complexometric titration was used to detect calcium(Ca)level,ELISA double antibody sandwich method was used to detect the level ofβ_(2)-microglobulin(β_(2)-MG),and the treatment effect and adverse reactions were counted.Result:Compared with the control treatment group,the levels of TG,LDL,LVEDD,IVST,LVPWT,hs-CRP,IL-6,TNF-α,AKP,Ca,PTH,β_(2)-MG and sTfR in the combined treatment group were significantly lower,and the HDL was significantly higher,the differences were statistically significant(P<0.05).Compared with the control treatment group,the total effective rate of the combined treatment group was higher,and the difference was statis
作者
张君琳
吴晶
王友云
ZHANG Junlin;WU Jing;WANG Youyun(不详;Affiliated Hospital of Jiangnan University,Wuxi 214000,China)
出处
《中外医学研究》
2022年第7期4-9,共6页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
无锡市中医药科科技项目(ZYKJ201901)。
