摘要
喹喔啉为一类重要的苯并吡嗪类杂环化合物,喹喔啉衍生物在医药及化工合成领域具有重要的作用。3-氯-2,6-二硝基喹喔啉是一种重要医药化工中间体。本文以2-羟基喹喔啉为原料,经硝化反应和氯代反应两步反应得到目标化合物。该合成方法操作简便、后处理操作简便,花费时间少且产物纯度高、收率也较高,产品收率为58.2%,适合工业化生产。
Quinoxaline is an important compound of benzopyrazine heterocycles. Quinoxaline derivatives play an important role in the field of medicine and chemical synthesis.3-chloro-2,6-dinitroquinoxaline is an important pharmaceutical and chemical intermediate. In this article, quinoxalin-2-ol was used as the starting material, and the target compound was obtained by two steps of nitrification and chlorination. The synthesis method is simple in operation, simple in post-treatment, taking less time in post-treatment and high in product purity and yield, and the product yield is 58.2 %, which is suitable for industrial production.
作者
高婷
周志旭
苏静杰
刘家芳
谢国旺
柴慧芳
Gao Ting;Zhou Zhixu;Su Jingjie;Liu Jiafang;Xie Guowang;Chai Huifang(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025;School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China)
出处
《广东化工》
CAS
2022年第6期18-20,共3页
Guangdong Chemical Industry
基金
贵州中医药大学2018年度学术新苗培养及创新探索专项项目培育项目计划(黔科台平台人才[2018]5766号-14)
贵州省科技计划项目:黔科合平台人才[2018]5781号。
