摘要
目的分析偏头痛脑白质病变(WML)的相关因素。方法收集135例偏头痛患者(偏头痛组)及118名健康对照者(正常对照组)的临床资料。对入组者进行头颅MRI检查,并采用Fazekas量表评分评价WML情况;采用TCD声学造影检查右向左分流(RLS)情况。结果偏头痛组WML发生率及深部WML(DWML)发生率显著高于正常对照组(χ^(2)=62.75,P<0.001;χ^(2)=4.888,P=0.027),两组间脑室周围WML(PWML)发生率差异无统计学意义(P=0.534)。偏头痛WML亚组年龄及RLS发生率显著高于无WML亚组(均P<0.05),而性别、偏头痛病程、先兆情况差异无统计学意义(均P>0.05)。二元Logistic回归分析显示,年龄大、合并RLS、RLS大分流量是偏头痛WML的危险因素(均P<0.01)。散点图显示,偏头痛患者WML评分与RLS分流量呈正相关。结论偏头痛患者WML发生率明显高于正常人。年龄大、合并RLS、大分流量RLS是偏头痛患者WML的危险因素。偏头痛患者WML程度越严重,RLS分流量越大。
Objective To analyze the related factors of white matter lesions(WML) in migraine.Methods Clinical data of 135 migraine patients(migraine group) and 118 healthy controls(normal control group) were collected. The subjects were examined by head MRI, and WML was evaluated by the Fazekas scale. Right-to-left shunt(RLS) was examined by TCD ultrasonography. Results The incidence of WML and deep WML(DWML) in migraine group were significantly higher than those in normal control group(χ^(2)=62.75, P<0.001;χ^(2)=4.888, P=0.027), there was no significant difference in the incidence of periventricular WML(PWML) between the two groups(P=0.534). Age and incidence of RLS in migraine WML subgroup were significantly higher than those in non-WML subgroup(all P<0.05), but there were no significant differences in gender, migraine course and aura(all P>0.05). Binary Logistic regression analysis showed that old age, patients with RLS, and large shunt RLS were risk factors for migraine in WML(all P<0.01). The scatter plot showed that the WML score was positively correlated with RLS flow in migraine patients. Conclusions The incidence of WML in migraine patients is significantly higher than that in normal controls. Old age, combined RLS and large shunt RLS are risk factors for WML in migraine patients. The more severe the WML degree of migraine patients is, the greater the RLS shunt volume is.
作者
潘心
迟蕊
隋晓雯
李福荣
赵红玲
PAN Xin;CHI Rui;SUI Xiao-wen(Department of Neurology,Dalian Central Hospital Affiliated to Dalian Medical University,Dalian 116033,China)
出处
《临床神经病学杂志》
CAS
2022年第1期19-23,共5页
Journal of Clinical Neurology
关键词
偏头痛
脑白质病变
右向左分流
相关因素
migraine
white matter lesions
right-to-left shunt
related factors
