摘要
目的研究血清鳞状细胞癌抗原(SCC-Ag)、可溶性E-钙黏蛋白(sE-cadherin)、人绒毛膜促性腺激素(β-HCG)在宫颈癌诊断中的应用价值。方法选取92例宫颈病变患者,根据术后病理检查结果分为宫颈上皮内瘤变组和宫颈癌组;同期选取50例于体检的健康人群作为对照组。比较三组血清SCC-Ag、sE-cadherin、β-HCG水平,根据标志物阳性表达情况比较SCC-Ag、sE-cadherin、β-HCG对宫颈癌诊断的灵敏度、特异性与准确度。结果宫颈上皮内瘤变组与宫颈癌组血清SCC-Ag、sE-cadherin、β-HCG水平高于对照组(P<0.05),且宫颈癌组血清SCC-Ag、sE-cadherin、β-HCG水平高于宫颈上皮内瘤变组(P<0.05)。SCC-Ag阳性表达52例、阴性表达90例,sE-cadherin阳性表达51例、阴性表达91例,β-HCG阳性表达50例、阴性表达92例。SCC-Ag对宫颈癌诊断的灵敏度为92.59%、特异性为97.73%、准确率为95.77%,sE-cadherin分别为88.89%、96.59%、93.66%,β-HCG分别为90.74%、98.86%、95.77%,三者联合分别为98.15%、98.86%、98.59%。血清SCC-Ag、sE-cadherin、β-HCG联合检测对宫颈癌的诊断效能显著优于单独检测(P<0.05)。结论血清SCC-Ag、sE-cadherin、β-HCG水平表达能有效反映宫颈癌病变程度,联合检测有助于提高宫颈癌诊断效能,可作为宫颈癌早期诊断评估的重要标志物。
Objective To investigate the value of serum squamous cell carcinoma antigen(SCC-Ag),soluble E-cadherin(sE-cadherin)and human chorionic gonadotropin(β-HCG)in the diagnosis of cervical cancer.Methods 92 patients with cervical lesions were enrolled and divided into 2 groups according to the pathological results,cervical intraepithelial neoplasia group(n=38)and cervical cancer group(n=54);Meantime,another 50 healthy individuals were set as the control group.Then serum levels of SCC-Ag,sE-cadherin andβ-HCG were compared among 3 groups,then the sensitivity,specificity and accuracy of SCC-AG,SE-cadherin andβ-HCG in the diagnosis of cervical cancer were compared.Results Serum levels of SCC-Ag,sE-cadherin andβ-HCG among 3 groups were the highest in cervical cancer group,followed by cervical intraepithelial neoplasia group,and were the lowest in the control group,with statistical difference(all P<0.05).There were 52 positive and 90 negative expressions of SCC-Ag,51 positive and 91 negative expressions of sE-cadherin,and 50 positive and 92 negative expressions ofβ-HCG.In the diagnosis of cervical cancer,the sensitivity,specificity and accuracy were 92.59%,97.73%and 95.77%under SCC-Ag curve,and were 88.89%,96.59%and 93.66%under sE-cadherin curve,and were 90.74%,98.86%and 95.77%underβ-HCG curve,while those were 98.15%,98.86%and 98.59%under the curve of combined detection of 3 indicators,indicating the combined detection of the 3 indicators had significantly better diagnostic efficacy than single detection(P<0.05).Conclusion SCC-AG,SE-cadherin andβ-HCG can effectively reflect the severity of cervical cancer,moreover,the combined detection of the 3 indicators is of great significance in the clinical diagnosis of cervical cancer,which can be used as markers in early diagnosis and evaluation.
作者
陈一蕊
勾朝阳
李新阳
CHEN Yirui;GOU Chaoyang;LI Xinyang(Nanyang Central Hospital,Nanyang,473000)
出处
《实用癌症杂志》
2022年第3期376-379,共4页
The Practical Journal of Cancer
基金
河南省医学科技攻关计划联合共建立项目(编号:LHGJ20200367)。
