摘要
目的:研究前列腺特异性抗原前体2型(p2PSA)、前列腺特异性抗原前体2型百分比(%p2PSA)及前列腺健康指数PHI值在前列腺癌诊断中的临床价值。方法:选取62例经临床病理首次诊断为前列腺癌患者作为实验组,同期良性前列腺增生患者70例作为对照组。测定所有患者的总PSA(tPSA),游离PSA(fPSA),p2PSA并计算f/tPSA、百分p2PSA(%p2PSA)及PHI值,观察比较各指标在两组患者中的表达差异,采用受试者工作特征(ROC)曲线评价各项指标对诊断前列腺癌的临床价值。结果:实验组和对照组年龄、血清fPSA水平差异无统计学意义(P均>0.05),tPSA、f/tPSA、p2PSA、%p2PSA及PHI值在两组间差异均有统计学意义(P均<0.01),ROC曲线分析结果显示,其诊断前列腺癌的AUC分别为0.874,0.853,0.956,0.930,0.963,PHI值、p2PSA、p2PSA%对前列腺癌的诊断价值优于其他指标。结论:与前列腺癌经典诊断指标相比,p2PSA、%p2PSA及PHI值在前列腺癌诊断中表现出更高的诊断效能,能有效降低前列腺癌的漏诊率,可作为前列腺癌的辅助诊断指标应用于临床。
Objective:To study the clinical value of prostate specific antigen precursor type 2(p2PSA),percentage of p2PSA and prostate health index(PHI)in the diagnosis of prostate cancer.Methods:Sixty-two patients with prostate cancer first diagnosed by clinicopathology were selected as the experimental group,and 70 patients with benign prostatic hyperplasia were selected as the control group.Total PSA(tPSA),free PSA(fPSA),P2PSA of all patients were measured and f/tPSA,percentage P2PSA(%P2PSA)and PHI values were calculated.The expression differences of each indicator in the two groups were observed and compared.The clinical value of each indicator in the diagnosis of prostate cancer was evaluated by receiver operating characteristic(ROC)curve.Results:the age and serum fPSA level has no statistical significance(P>0.05),tPSA,f/tPSA,p2PSA,%p2PSA and PHI differences between the two groups have statistical significance(P<0.01),the ROC curve analysis,according to the results of the diagnosis of prostate cancer AUC were 0.874,0.853,0.956,0.930,0.963,The value of PHI,P2PSA and%P2PSA in the diagnosis of prostate cancer is better than other indexes.Conclusion:Compared with the classical diagnostic indicators of prostate cancer,P2PSA,%P2PSA and PHI have higher diagnostic efficiency in the diagnosis of prostate cancer,which can effectively reduce the rate of missed diagnosis of prostate cancer,and can be used as auxiliary diagnostic indicators of prostate cancer in clinical application.
作者
公帅
刘宗英
GONG Shuai;LIU Zong-ying(Department of Clinical Laboratory medicine,People's Hospital of Pingyi County,Shandong Linyi 273300)
出处
《医学检验与临床》
2022年第2期14-17,共4页
Medical Laboratory Science and Clinics
