摘要
Background:With lifestyle modification and over-nutrition,the prevalence of nonalcoholic fatty liver disease(NAFLD)has been increasing annually.Here we aimed to assess the updated prevalence of NAFLD,and to evaluate the association of NAFLD with metabolic abnormalities according to gender,body mass index and age.Methods:A population-based cross-sectional study was conducted in Shanghai from December 2016 to July 2017.With a three-stage stratified sampling strategy,3,717 eligible participants were enrolled for the analysis.Results:In total,1,217 subjects(32.7%)had NAFLD.Among them,400(16.3%)of the nonobese and 817(65.0%)of the obese subjects had NAFLD.The prevalence of NAFLD was increased according to the quartiles of age and waist circumference(WC)in the nonobese subjects.Females with nonobese NAFLD had 1.6-,2.6-,2.0-,2.3-and 3.3-fold higher risks for metabolic syndrome,diabetes mellitus,hyperglycemia,hypertriglycerdemia(high TG)and low high-density lipoprotein cholesterol than obese subjects without NAFLD,respectively.Males had comparable metabolic profiles in both groups,except for a 2.0-fold higher risk of high TG in nonobese NAFLD subjects compared with obese subjects without NAFLD.More impressively,the homeostasis metabolic assessment insulin resistance index was comparable between the two groups.Conclusions:The increase of age and WC had significant impact on the risk of NAFLD in nonobese subjects.The presence of NAFLD in nonobese subjects increased the risk of metabolic diseases than obese subjects without NAFLD,especially in female.
基金
This work was supported by grants from the Three-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System(2015-2017)(No.GWIV-27.7).
