摘要
膜性肾病(MN)是肾内科难治疾病之一,分为原发性膜性肾病(PMN)和继发性膜性肾病(SMN)。肾活检显示,MN发生率达到了22%左右。目前尚缺乏对MN的具体诊断,因此有必要进一步探讨其发病机制和生物标记物。本文从免疫异常、遗传因素、环境因素方面探究MN的发病机制。抗磷脂酶A2受体(PLA2R)是甘露糖受体家族的跨膜糖蛋白成员,他在人类肾脏中表达最强烈。尽管抗PLA2R检测MN的特异度基本上是100%,但在一定程度上模糊了PMN和SMN疾病的区别。因此本文除了着重综述PLA2R以外,还综述了其他几种新发现的生物标记物,旨在进一步为临床诊断与治疗提供帮助。
Membranous nephropathy(MN)is one of the refractory diseases in nephrology,which is divided into primary membranous nephropathy(PMN)and secondary membranous nephropathy(SMN).Renal biopsy showed that the incidence of MN reached about 22%.At present,there is no specific diagnosis of MN,so it is necessary to further explore its pathogenesis and biomarkers.This paper explores the pathogenesis of MN from the aspects of immune abnormalities,genetic factors and environmental factors.Anti-phospholipase A2 receptor(PLA2R),a transmembrane glycoprotein member of the mannose receptor family,is most strongly expressed in human kidney.Although the specificity of anti-PLA2R in the diagnosis of MN is basically 100%,it blurs the difference between PMN and SMN to a certain extent.Therefore,in addition to focusing on PLA2R,this paper also reviews several other newly discovered biomarkers in order to further help clinical diagnosis and treatment.
作者
钱虹洁
白长川
刘璐
赵杨佳宁
周悦
关卿
王大鹏
QIAN Hongjie;BAI Changchuan;LIU Lu;ZHAO-YANG Jianing;ZHOU Yue;GUAN Qing;WANG Dapeng(the First Affiliated Hospital of Dalian Medical University,Dalian 116011;College of Integrated Traditional Chinese and Western Medicine/Institute of Integrated Traditional Chinese and Western Medicine,Dalian Medical University,Dalian 116044;Dalian Hospital of Traditional Chinese Medicine,Dalian 116013,China)
出处
《临床医学研究与实践》
2022年第10期196-198,共3页
Clinical Research and Practice
关键词
原发性膜性肾病
继发性膜性肾病
发病机制
抗磷脂酶A2受体
primary membranous nephropathy
secondary membranous nephropathy
pathogenesis
anti-phospholipase A2 receptor
