摘要
目的 探究常规复苏结合纳洛酮及糖皮质激素对心脏骤停患者复苏成功率的影响。方法 回顾性选择2018年2月至2021年1月我院急诊科收治的100例心脏骤停患者作为研究对象,按不同急救方案将其分为对照组(48例,常规复苏+糖皮质激素抢救)与研究组(52例,常规复苏+糖皮质激素+纳洛酮抢救)。比较两组的自主呼吸、自主意识及自主循环恢复时间,APACHEⅡ、GCS评分、血清SOD、MDA水平、复苏情况及48 h存活情况。结果 研究组的自主呼吸、自主意识、自主循环恢复时间均明显短于对照组(P<0.05)。用药后,两组的APACHEⅡ评分均低于用药前,GCS评分均高于用药前,且研究组优于对照组(P<0.05)。用药后,研究组的血清SOD水平显著高于对照组,MDA水平显著低于对照组(P<0.05)。研究组的复苏成功率及存活率均显著高于对照组,差异具有统计学意义(P<0.05)。结论 急诊抢救心脏骤停患者时给予常规复苏结合纳洛酮及糖皮质激素可提高复苏成功率,加速患者自主呼吸、意识、循环恢复,减轻氧化应激反应。
Objective To explore the effects of routine resuscitation combined with naloxone and glucocorticoid on resuscitation success rate in patients with cardiac arrest. Methods A total of 100 patients with cardiac arrest treated in the emergency department of our hospital from February 2018 to January 2021 were retrospectively selected as the research objects. According to different first aid schemes, the patients were divided into control group(48 cases, routine resuscitation + glucocorticoid rescue) and study group(52 cases, routine resuscitation + glucocorticoid + naloxone rescue). The recovery time of autonomic breathing, autonomic consciousness and autonomic circulation, APACHE Ⅱ and GCS scores, serum SOD and MDA levels, recovery and 48 h survival were compared between the two groups. Results The recovery time of autonomic breathing, autonomic consciousness and autonomic circulation in the study group were significantly shorter than those in the control group(P<0.05). After medication, the APACHEⅡ score in the two groups was lower than that before treatment, while the GCS score was higher than that before treatment, and those in the study group were better than the control group(P<0.05). After medication, the level of serum SOD in the study group was significantly higher than that in the control group, while the level of MDA was significantly lower than that in the control group(P<0.05).The resuscitation success rate and survival rate in the study group were significantly higher than those in the control group, and the differences were statistically significant(P <0.05). Conclusion Routine resuscitation combined with naloxone and glucocorticoid can improve the success rate of resuscitation in emergency rescue of patients with cardiac arrest, accelerate the recovery of spontaneous breathing, consciousness and circulation, and reduce oxidative stress.
作者
夏腾飞
XIA Tengfei(Emergency Department,the First People's Hospital of Zhumadian,Zhumadian 463000,China)
出处
《临床医学研究与实践》
2022年第10期58-60,共3页
Clinical Research and Practice
关键词
心脏骤停
常规复苏
纳洛酮
糖皮质激素
复苏成功率
cardiac arrest
routine resuscitation
naloxone
glucocorticoid
resuscitation success rate
