摘要
目的 探讨单侧入路经皮椎体后凸成形术(PKP)治疗胸腰椎骨质疏松性骨折的效果。方法 选取2019年1月至2021年1月我院收治的300例胸腰椎骨质疏松性骨折患者,以抽签法按单双号分组形式随机将其分为对照组和观察组,各150例。对照组采用双侧入路PKP治疗,观察组采用单侧入路PKP治疗。比较两组的治疗效果。结果 术后1 d,观察组的椎体平均高度高于对照组,椎体Cobb角小于对照组,差异具有统计学意义(P<0.05)。观察组的手术时间、X线暴露时间明显短于对照组,骨水泥用量明显少于对照组,差异具有统计学意义(P<0.05)。术后1 d,两组的CRP、E、Cor水平均升高,但观察组低于对照组,差异具有统计学意义(P<0.05)。术后3个月,观察组TPⅠNP、β-CTX、OPG水平低于对照组,25-(OH)D、BGP、ALP水平高于对照组,差异具有统计学意义(P<0.05)。结论 临床采用单侧入路PKP治疗胸腰椎骨质疏松性骨折利于缩短手术时间和X线暴露时间,减少骨水泥用量,减轻机体创伤应激反应,也能改善骨代谢指标,值得推广。
Objective To explore the effect of unilateral approach percutaneous kyphoplasty(PKP) in the treatment of thoracolumbar vertebral osteoporotic fractures. Methods A total of 300 patients with thoracolumbar vertebral osteoporotic fractures admitted in our hospital from January 2019 to January 2021 were selected and randomly divided into control group and observation group by lottery according to the odd and even numbers, with 150 cases in each group. The control group was treated with bilateral approach PKP, and the observation group was treated with unilateral approach PKP. The therapeutic effects of the two groups were compared. Results One day after operation, the average height of vertebral body in the observation group was higher than that in the control group, and the Cobb angle of vertebral body was smaller than that in the control group, the differences were statistically significant(P<0.05). The operation time and X-ray exposure time in the observation group were significantly shorter than those in the control group, and the amount of bone cement was significantly less than that in the control group, the differences were statistically significant(P <0.05). One day after operation, the levels of CRP, E and Cor in the two groups increased, but those in the observation group were lower than the control group, the differences were statistically significant(P<0.05). Three months after operation, the levels of TPⅠNP,β-CTX, OPG in the observation group were lower than those in the control group, and the levels of 25-(OH)D, BGP and ALP were higher than those in the control group, the differences were statistically significant(P<0.05). Conclusion The unilateral approach PKP in the treatment of thoracolumbar vertebral osteoporotic fractures is beneficial to shorten the operation time, X-ray exposure time, reduce the amount of bone cement and the body’s traumatic stress response, and improve the indexes of bone metabolism, which is worth promoting.
作者
李佳平
李龙
李敏
LI Jiaping;LI Long;LI Min(the People's Hospital of Fu County,Yan'an 727500;Shangluo Central Hospital,Shangluo 726000;Sun Si Miao Hospital of BUCM/Tongchuan Hospital of Traditional Chinese Medicine,Tongchuan 727000,China)
出处
《临床医学研究与实践》
2022年第10期42-45,共4页
Clinical Research and Practice
基金
北京中医药大学2018年度校级课题(京外附属医院)(No.2018-BUCMXJKY018)。
关键词
单侧入路
经皮椎体后凸成形术
胸腰椎骨质疏松性骨折
创伤应激反应
骨代谢
unilateral approach
percutaneous kyphoplasty
thoracolumbar vertebral osteoporotic fractures
traumatic stress response
bone metabolism
