摘要
目的探究老年恶性血液病患者真菌感染的危险因素。方法选取2016年5月~2018年5月住院治疗的老年恶性血液病患者146例为研究对象,对其发生真菌感染的危险因素进行分析。结果146例患者发生真菌感染例数为45例(30.82%)。单因素分析结果显示,是否使用预防性抗真菌药、是否患有慢性病、抗生素使用时间不同、外周血白细胞最低计数不同、粒细胞缺少时间不同的患者真菌感染率不同,差异均有统计学意义(P<0.05)。logistic回归分析显示,未预防性使用抗真菌药、抗生素使用时间≥7d、外周血白细胞最低计数<109/L、粒细胞缺少时间≥7d为老年恶性血液病真菌感染的独立危险因素(P<0.05)。结论针对影响老年恶性血液病患者发生真菌感染的危险因素,在治疗过程中应合理应用抗生素以及预防性抗真菌药物,同时给予有效干预措施以改善感染情况。
Objective To explore the risk factors for fungal infection in older patients with malignant hematological diseases.Methods A total of 146 older patients with malignant hematological diseases hospitalized in Kailuan General Hospital from May 2016 to May 2018 were selected in this study.The risk factors for fungal infection were analyzed.Results Fungal infection appeared in 45 cases(30.82%).Univariate analysis revealed that the fungal infection rate varied with the use of preventive antifungal drugs, chronic diseases, length of antibiotic use, minimum peripheral white blood cell counts and duration of granulocyte deficiency, the differences were statistically significant(P<0.05).Logistic regression analysis showed that no preventive use of antifungal drugs, duration of antibiotic treatment≥7 d, minimum peripheral white blood cell counts<10;/L,and duration of granulocyte deficiency≥7 d were independent risk factors for fungal infection in older patients with malignant hematological diseases(P<0.05).Conclusion According to the analysis of the risk factors of fungal infection in older patients with malignant hematological diseases, antibiotics and preventive antifungal drugs should be reasonably used in the treatment process, and effective intervention should be given to avoid the infection.
作者
纪文哲
徐莉莉
潘红
张涛
Ji Wenzhe;Xu Lili;Pan Hong;Zhang Tao(Kailuan General Hospital,Tangshan 063000)
出处
《国际老年医学杂志》
2022年第2期216-218,共3页
International Journal of Geriatrics
基金
河北省医学科学重点研究课题计划(20181449)。
关键词
老年恶性血液病
真菌感染
危险因素
干预
Malignant hematological diseases
Fungal infection
Risk factors
Intervention
