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齐拉西酮联合氯丙嗪治疗老年精神分裂症的效果及对NGF、BDNF、K^(+)水平的影响 被引量:2

Effects of Ziprasidone Combined with Chlorpromazine on NGF,BDNF and K^(+) Levels in Senile Schizophrenia
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摘要 目的:探究齐拉西酮联合氯丙嗪治疗老年精神分裂症的效果及对神经生长因子(nerve growth factor,NGF)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、血钾离子(K^(+))水平的影响。方法:选取2017年1月-2019年1月无锡市精神卫生中心精神科收治的100例老年精神分裂症患者,按照随机数字表法分为对照组(n=50)、联合组(n=50)。对照组采用氯丙嗪治疗,联合组采用齐拉西酮联合氯丙嗪治疗。检测两组患者精神症状、认知功能、神经营养因子、心电图、血K^(+)、血镁离子(Mg^(2+))水平,比较两组患者治疗效果及不良反应发生情况。结果:治疗后,联合组患者简明精神状态量表(mini-mental state examination,MMSE)评分、认知功能、NGF、BDNF水平均高于对照组,阳性与阴性症状量表(PANSS)评分、神经元特异性烯醇化酶(neuron specific enolase,NSE)、髓鞘碱性蛋白(myelin basic protein,MBP)、手型钙结合蛋白(S100B)水平均低于对照组(P<0.05)。联合组、对照组患者Q-T间期(QTc)、K^(+)、血Mg^(2+)相比,差异均无统计学意义(P>0.05)。联合组患者治疗总有效率高于对照组(P<0.05)。结论:齐拉西酮联合氯丙嗪可显著改善老年精神分裂症患者精神症状,通过改善NGF、BDNF等神经营养因子异常表达,修复受损神经元,且不影响患者机体电解质平衡,效果显著。 Objective:To explore the effect of Ziprasidone combined with Chlorpromazine on senile schizophrenia and its effect on nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF)and potassium ion(K^(+)).Method:A total of 100 elderly patients with schizophrenia admitted to the Department of Psychiatry of Wuxi Mental Health Center from January 2017 to January 2019 were randomly divided into control group(n=50)and combined group(n=50).The control group was treated with Chlorpromazine,while the combined group was treated with Ziprasidone combined with Chlorpromazine.The mental symptoms,cognitive function,neurotrophic factors,electrocardiogram,blood K^(+) and magnesium ion(Mg^(2+))levels of the two groups of patients were detected,and the therapeutic effects and adverse reactions of the two groups of patients were compared.Result:After treatment,MMSE score,cognitive function,NGF and BDNF levels in combined group were higher than those in control group,positive and negative symptom scale(PANSS)score,neuron specific enolase(NSE),myelin basic protein,the levels of MBP and S100B were lower than those of control group(P<0.05).There were no significant differences in QT interval(QTc),K^(+) and blood Mg^(2+) between the combined group and the control group(P>0.05).The total effective rate in combined group was higher than that in control group(P<0.05).Conclusion:Ziprasidone combined with Chlorpromazine can significantly improve the mental symptoms of elderly patients with schizophrenia,and repair damaged neurons by improving the abnormal expression of NGF,BDNF and other neurotrophic factors,without affecting the electrolyte balance of patients.
作者 季莉 唐琳 杨涛 吕振雷 陈潇逸 袁宏伟 JI Li;TANG Lin;YANG Tao;LYU Zhenlei;CHEN Xiaoyi;YUAN Hongwei(Wuxi Mental Health Center,Jiangsu Province,Wuxi 214000,China;不详)
出处 《中国医学创新》 CAS 2022年第5期160-164,共5页 Medical Innovation of China
关键词 齐拉西酮 氯丙嗪 精神分裂症 神经生长因子 脑源性神经营养因子 Ziprasidone Chlorpromazine Schizophrenia Nerve growth factor Brain-derived neurotrophic factor
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