摘要
目的:观察依托咪酯联合丙泊酚在腹腔镜胆囊切除术患者中的应用效果。方法:回顾性分析2018年9月至2020年5月该院收治的88例行腹腔镜胆囊切除术患者的临床资料,按照麻醉诱导方法不同分为对照组和研究组各44例。对照组给予丙泊酚进行麻醉诱导,研究组在对照组的基础上联合依托咪酯进行麻醉诱导,比较两组不同时间点[诱导前(T_(0))、诱导后3 min(T_(1))、插管后即刻(T_(2))、插管后3 min(T_(3))]血流动力学指标[收缩压(SBP)、心率(HR)、血氧饱和度(SaO_(2))]水平,诱导前及术后3、12 h炎性因子[血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,术后恢复时间,以及不良反应发生率。结果:T_(1)、T_(2)、T_(3)时,研究组SBP、HR水平均低于对照组,SaO_(2)水平高于对照组,差异有统计学意义(P<0.05);术后3、12 h,研究组IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);研究组住院时间、拔管时间及睁眼时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:依托咪酯联合丙泊酚应用于腹腔镜胆囊切除术患者,可稳定血流动力学指标水平,降低炎性因子水平,缩短术后恢复时间,且安全性较高,其麻醉诱导效果优于单独应用丙泊酚。
Objective:To observe application effects of Etomidate combined with Propofol in patients undergoing laparoscopic cholecystectomy.Methods:The clinical data of 88 patients who underwent laparoscopic cholecystectomy in our hospital from September 2018 to May 2020 were retrospectively analyzed.According to different anesthesia induction methods,they were divided into control group and study group,with 44 cases in each group.The control group was given Propofol for anesthesia induction,while the study group was given Etomidate for anesthesia induction on the basis of that of the control group.The hemodynamic index levels[systolic blood pressure(SBP),heart rate(HR),blood oxygen saturation(SaO_(2))]at different time points[before induction(T_(0)),3 minutes after induction(T_(1)),immediately after intubation(T_(2)),3 minutes after intubation(T_(3))],the inflammatory factor index levels[serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)before induction and 3 and 12 h after the surgery,the postoperative recovery time and the incidence of adverse reactions were compared between the two groups.Results:At T_(1),T_(2) and T_(3),the levels of SBP,HR in the study group were lower than those in the control group,and the level of SaO_(2) was higher than that in the control group,and the differences were statistically significant(P<0.05).3 and 12 h after the surgery,the levels of IL-6 and TNF-αin the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The hospitalization time,the extubation time and the eye opening time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Etomidate combined with Propofol for the patients undergoing laparoscopic cholecystectomy can stabilize the levels of hemodynamic indexes,reduce the levels of inflammatory factors,and shorten the postop
作者
麻黎斯
MA Lisi(Department of Anesthesiology of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000 Henan,China)
出处
《中国民康医学》
2022年第4期30-33,共4页
Medical Journal of Chinese People’s Health
关键词
腹腔镜胆囊切除术
依托咪酯
丙泊酚
麻醉诱导
血流动力学
炎性因子
不良反应
Laparoscopic cholecystectomy
Etomidate
Propofol
Anesthesia induction
Hemodynamics
Inflammatory factor
Adverse reaction
