摘要
目的:探讨急性心肌梗死(AMI)患者给予参芪血府逐瘀汤联合麝香保心丸治疗对心功能及C反应蛋白(CRP)水平的影响。方法:选取2017年1月-2019年12月在广州中医药大学附属东莞医院治疗的AMI患者120例作为研究对象,按照随机数字表法分为观察组(n=60)和对照组(n=60)。对照组给予麝香保心丸治疗,观察组在对照组的基础上联合参芪血府逐瘀汤治疗。比较两组临床疗效、心功能、炎性因子水平及血清血管新生因子水平。结果:与对照组相比,观察组治疗总有效率明显更高(P<0.05)。治疗后,两组左心室射血分数(LVEF)、每搏输出量(SV)较治疗前均明显提高,B型脑钠肽(BNP)水平较治疗前明显降低,且观察组LVEF、SV均高于对照组,BNP水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、CRP水平较治疗前均明显降低,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平较治疗前均明显提高,且观察组均高于对照组,差异均有统计学意义(P<0.05)。结论:AMI患者给予参芪血府逐瘀汤联合麝香保心丸治疗,能提高临床疗效,改善患者心功能、炎性因子水平及血清血管新生因子水平,应用价值较高。
Objective:To investigate the effect of Shenqi Xuefu Zhuyu Decoction combined with Shexiang Baoxin Pills on cardiac function and C-reactive protein (CRP) level in patients with acute myocardial infarction (AMI).Method:A total of 120 patients with AMI treated in Dongguan Hospital Affiliated to Guangzhou University of Chinese Medicine from January 2017 to December 2019 were selected as the research subjects,and they were divided into the observation group (60 cases) and the control group (60 cases) according to random number table method.The control group was treated with Shexiang Baoxin Pills,and the observation group was treated with Shenqi Xuefu Zhuyu Decoction on the basis of the control group.Clinical efficacy,cardiac function,inflammatory factor levels and serum angiogenic factor levels were compared between two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).After treatment,the left ventricular ejection fraction (LVEF) and stroke volume (SV) in two groups were significantly increased,and the levels of B-type brain natriuretic peptide (BNP) were significantly decreased,the LVEF and SV in the observation group were significantly higher than those in the control group,and the BNP level was significantly lower than that in the control group,the differences were statistically significant (P<0.05).After treatment,the levels of interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) and CRP in two groups were significantly decreased,and the observation group were significantly lower than those in the control group,the differences were statistically significant (P<0.05).After treatment,the levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in two groups were significantly increased,and the observation group were significantly higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion:In AMI patients,Shenqi Xuefu Zhuyu Decoction combined with Shexiang
作者
范彩霞
陈彦姗
陈润娣
FAN Caixia;CHEN Yanshan;CHEN Rundi(Dongguan Hospital Affiliated to Guangzhou University of Chinese Medicine,Dongguan 523000,China;不详)
出处
《中国医学创新》
CAS
2022年第3期120-124,共5页
Medical Innovation of China
关键词
参芪血府逐瘀汤
麝香保心丸
急性心肌梗死
心功能
C反应蛋白
Shenqi Xuefu Zhuyu Decoction
Shexiang Baoxin Pills
Acute myocardial infarction
Cardiac function
C-reactive protein
