摘要
目的:探究与观察乙肝肝硬化患者血清纤维化相关指标及红细胞免疫状态的变化情况。方法:选取2019年1月-2021年3月辽宁省大连市公共卫生临床中心收治的100例乙肝肝硬化患者为A组,同时期的100例乙肝无肝硬化患者为B组,100名体检健康者为C组。比较三组的血清纤维化指标(HA、LN、Ⅳ-C)水平及红细胞免疫指标[免疫黏附促进因子(FEER)、免疫黏附抑制因子(FEIR)、红细胞C3b受体花环率(RBC-C3bR)、红细胞免疫复合物花环率(RBC-ICR)]水平,比较A组中不同Child-Pugh分级患者的上述血清纤维化相关指标及红细胞免疫指标,采用Spearman秩相关分析上述血清指标与乙肝肝硬化Child-Pugh分级的关系。结果:A组HA、LN、Ⅳ-C水平均高于B组和C组,且B组均高于C组,差异均有统计学意义(P<0.05)。A组FEIR、RBC-ICR水平均高于B组及C组,且B组均高于C组,A组FEER及RBC-C3bR均低于B组及C组,且B组均低于C组,差异均有统计学意义(P<0.05)。Child-Pugh为A级患者HA、LN、Ⅳ-C水平均低于Child-Pugh为B级和Child-Pugh为C级患者,且Child-Pugh为B级患者均低于Child-Pugh为C级患者,差异均有统计学意义(P<0.05)。Child-Pugh为A级患者的FEIR、RBC-ICR水平均低于Child-Pugh为B级及Child-Pugh为C级患者,且Child-Pugh为B级患者均低于Child-Pugh为C级患者,Child-Pugh为A级患者的FEER及RBC-C3bR均高于Child-Pugh为B级及Child-Pugh为C级患者,且Child-Pugh为B级患者均高于Child-Pugh为C级患者,差异均有统计学意义(P<0.05)。Spearman秩相关分析显示,血清纤维化指标及FEIR、RBC-ICR与乙肝肝硬化Child-Pugh分级均呈正相关,FEER及RBC-C3bR与乙肝肝硬化Child-Pugh分级均呈负相关(P<0.05)。结论:乙肝肝硬化患者的血清纤维化相关指标及红细胞免疫状态相对异常,且其表达水平与疾病分级密切相关,因此在乙肝肝硬化患者中的检测价值较高。
Objective:To investigate and observe the change situation of serum fibrosis related indexes and erythrocyte immune status of patients with cirrhosis caused by Hepatitis B.Method:A total of 100 patients with cirrhosis caused by Hepatitis B in Dalian Public Health Clinical Center from January 2019 to March 2021 were chosen as the group A,100 patients with Hepatitis B and without cirrhosis at the same time were chosen as the group B,100 healthy person with physical examination were chosen as the group C.Then the serum fibrosis related indexes(HA,LN,Ⅳ-C) and erythrocyte immune indexes[Immunoadhesion promoter (FEER),immunoadhesion inhibitor (FEIR),erythrocyte C3b receptor rosette rate (RBC-C3bR),erythrocyte immune complex rosette rate (RBC-ICR)]of three groups were detected and compared,then those serum fibrosis related indexes and erythrocyte immune indexes of observation group with different Child-Pugh classifications were compared,and the correlation between those fibrosis related indexes,erythrocyte immune indexes and Child-Pugh classifications of cirrhosis caused by Hepatitis B were analyzed with Spearman rank correlation analysis.Result:The HA,LN and Ⅳ-C levels in the group A were higher than those in the group B and group C,and those in the group B were higher than those in the group C,the differences were statistically significant (P<0.05).The FEIR and RBC-ICR levels in the group A were higher than those in the group B and C,and those in the group B were higher than those in the group C,FEER and RBC-C3bR levels in the group A were lower than those in the group B and C,and those in the group B were lower than those in the group C,the differences were statistically significant (P<0.05).The HA,LN and Ⅳ-C levels of Child-Pugh grade A patients were lower than those of Child-Pugh grade B and Child-Pugh grade C patients,and those of the Child-Pugh grade B patients were lower than those of the Child-Pugh grade C patients,the differences were statistically significant (P<0.05).The FEIR and RBC-ICR levels of Child
作者
汪洋
WANG Yang(Dalian Public Health Clinical Center,Liaoning Province,Dalian 116013,China)
出处
《中国医学创新》
CAS
2022年第6期19-23,共5页
Medical Innovation of China
关键词
乙肝肝硬化
血清
纤维化相关指标
红细胞免疫状态
Cirrhosis caused by Hepatitis B
Serum
Fibrosis related indexes
Erythrocyte immune status
