摘要
目的探讨和肽素(CPP)和组织激肽释放酶结合蛋白(KS)在冠状动脉粥样硬化(CAS)患者血清中的含量及其与冠脉狭窄程度的关系。方法选取2019年10月~2020年10月本院收治的196例CAS患者的临床资料,同时收集同期同年龄层来院体检的190例健康者的临床资料。将CAS患者作为观察组,健康体检者作为对照组,比较两组的CPP、KS及临床资料的差异。通过二元Logistic回归分析CAS的独立危险因素。通过受试者工作特征曲线(ROC)预测CPP和KS对重度CAS的诊断价值。结果观察组的CPP较对照组明显升高,KS较对照组明显下降(均P<0.05)。CPP随着CAS狭窄程度加重而增加,KS随着CAS狭窄程度加重而降低(均P<0.05)。二元Logistic回归分析显示,CPP、KS及高密度脂蛋白是影响CAS发生的独立危险因素(均P<0.05)。ROC曲线显示,CPP联合KS的AUC值(0.830)明显高于单一CPP或KS的AUC值(0.758或0.741),其灵敏度和特异度分别为86.54和87.97(P<0.05)。结论血清中CPP在CAS中上升,而KS在CAS中下降,两者与CAS的狭窄程度密切相关,且CPP联合KS对重度CAS狭窄具有良好的诊断效能,对指导临床早期防治具有重要意义。
Objective To investigate the content of copeptin(CPP)and kallistatin(KS)in serum of patients with coronary atherosclerosis(CAS)and their relationship with the degree of coronary artery stenosis.Methods The clinical data of 196 patients with CAS treated in our hospital from October 2019 to October 2020 were selected,and the clinical data of 190 healthy persons of the same age were collected at the same time.Taking the patients with CAS as the observation group and the healthy persons as the control group.The differences of CPP,KS and clinical data were compared.The independent risk factors of CAS was analyzed by binary Logistic regression.The predicting value of CPP and KS in the diagnosis of severe CAS were evaluated by the receiver working characteristic curve(ROC).Results CPP of the observation group was significantly higher than that of the control group,while KS was significantly lower than that of the control group(all P<0.05).CPP increases with the degree of increasing CAS stenosis,while KS decreases with the degree of increasing CAS stenosis(all P<0.05).Binary Logistic regression analysis showed that CPP,KS and high density lipoprotein were independent risk factors for the occurrence of CAS(all P<0.05).The ROC curve showed that the AUC value(0.830)of CPP combined with KS was significantly higher than that of a single CPP or KS(0.758 or 0.741),and its sensitivity and specificity were 86.54 and 87.97,respectively(all P<0.05).Conclusion In serum,CPP increased in CAS and KS decreased in CAS,both of which are closely related to the degree of CAS stenosis.Moreover,CPP combined with KS has a good diagnostic efficacy for severe CAS stenosis,which is of great significance for guiding the early clinical prevention and treatment.
作者
崔国艳
高虹
李丽晶
郑雯
CUI Guoyan;GAO Hong;Li Lijing;ZHENG Wen(Special Ward, Liaoyang Central Hospital, Liaoyang 111000, Liaoning, China;Department of Cardiovascular Medicine, Liaoyang Central Hospital, Liaoyang 111000, Liaoning, China)
出处
《西部医学》
2022年第3期443-447,共5页
Medical Journal of West China
基金
辽宁省自然科学基金(2019060355-041)。
