摘要
目的分析多烯磷脂酰胆碱联合地塞米松治疗妊娠期肝内胆汁淤积症(ICP)的效果。方法选取2019年1月至2020年2月佳木斯市妇幼保健院收治的70例ICP患者,采用随机数字表法分为对照组(n=35,地塞米松治疗)和观察组(n=35,地塞米松+多烯磷脂酰胆碱治疗),疗程均为2周。比较两组临床症状改善情况,血清甘胆酸(CG)、总胆汁酸(TBA)水平变化,疗效及围产结局。结果治疗后,两组瘙痒评分较治疗前降低,且观察组低于对照组(P<0.001),观察组瘙痒消失时间、黄疸消失时间短于对照组(P<0.001);治疗后,两组血清CG、TBA水平均较治疗前降低,其中观察组血清CG、TBA水平低于对照组(P<0.001);观察组总有效率为94.29%,高于对照组的74.29%(P<0.05);观察组不良围产结局总发生率为25.71%,低于对照组的51.43%(P<0.05)。结论地塞米松+多烯磷脂酰胆碱治疗ICP能够使黄疸、瘙痒症状快速消失,降低血清CG、TBA水平,提升疗效,改善围产结局。
Objective To analyze the efficacy of polyene phosphatidylcholine combined with dexamethasone in the treatment of intrahepatic cholestasis of pregnancy(ICP).Methods A total of 70 patients with ICP admitted to and treated in Jiamusi Maternal and Child Health-care Hospital from January 2019 to February 2020 were selected,and they were divided into the control group(n=35)and the observation group(n=35)according to the random number table method.The control group was treated with dexamethasone,while the observation group was treated with polyene phosphatidylcholine on the basis of the control group.Both courses of treatment were two weeks.The improvement of clinical symptoms,changes of serum cholyglycine(CG)and total bile acid(TBA),therapeutic efficacy and perinatal outcome were compared between the two groups.Results After treatment,the pruritus scores of the two groups were lower than those before treatment,and the observation group was lower than that of the control group(P<0.001).The disappearance time of pruritus and jaundice in the observation group was shorter than that in the control group(P<0.001).After treatment,the levels of serum CG and TBA in both groups were lower than those before treatment,and the levels of serum CG and TBA in the observation group were lower than those in the control group(P<0.001).The total effective rate of the observation group was 94.29%,which was higher than 74.29%of the control group(P<0.05).The total incidence of adverse perinatal outcome in the observation group was 25.71%,which was lower than 51.43%in the control group(P<0.05).Conclusion Polyene phosphatidylcholine combined with dexamethasone in the treatment of ICP can obviously improve the clinical symptoms,reduce the levels of serum CG and TBA,increase the therapeutic efficacy and boost the perinatal outcome.
作者
肖晓超
XIAO Xiaochao(Department of Gynecology and Obstetrics,Jiamusi Maternal and Child Health-care Hospital in Heilongjiang Province,Jiamusi154007,China)
出处
《中国现代医生》
2022年第4期64-66,74,共4页
China Modern Doctor
关键词
妊娠期肝内胆汁淤积症
多烯磷脂酰胆碱
地塞米松
围产结局
Intrahepatic cholestasis of pregnancy
Polyene phosphatidylcholine
Dexamethasone
Perinatal outcome
