摘要
目的分析老年稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)术前血清鸢尾素(Irisin)、Preptin水平及二者与患者PCI术后预后的关系。方法选取2019年6月—2020年8月山东第一医科大学附属中心医院收治的老年稳定型心绞痛患者96例为研究组,同期体检健康者96例为健康对照组。检测2组血清Irisin、Preptin水平,研究组患者PCI术前进行冠状动脉Gensini评分;PCI术后随访1年,根据患者是否发生心血管事件分为预后良好亚组86例和预后不良亚组10例;分析PCI术前血清Irisin、Preptin与Gensini评分的相关性,Logistic回归分析影响老年稳定型心绞痛患者PCI术后预后的因素,ROC分析PCI术前血清Irisin、Preptin对老年稳定型心绞痛患者PCI术后预后不良的预测价值。结果研究组PCI术前血清Irisin、Preptin水平均显著低于健康对照组(t/P=21.655/<0.001、9.424/<0.001);单支血管病变亚组、双支血管病变亚组、三支血管病变亚组PCI术前血清Irisin、Preptin水平依次降低(F/P=198.629/<0.001、44.409/<0.001);预后不良亚组PCI术前血清Irisin、Preptin水平低于预后良好亚组,Gensini评分高于预后良好亚组(t/P=8.963/<0.001、3.533/0.001、10.226/<0.001);老年稳定型心绞痛患者PCI术前血清Irisin与Preptin水平呈正相关(r/P=0.591/<0.001),血清Irisin、Preptin水平均与Gensini评分呈负相关(r/P=-0.442/<0.001、-0.454/<0.001);PCI术前血清Irisin、Preptin低水平及Gensini高评分是老年稳定型心绞痛患者PCI术后预后不良的危险因素[OR(95%CI)=2.104(1.225~3.614)、1.937(1.067~3.515)、1.816(1.027~3.212)];PCI术前血清Irisin、Preptin水平及两者联合预测老年稳定型心绞痛患者PCI术后预后不良的曲线下面积分别为0.809、0.774、0.913,两者联合优于单独预测(Z/P=1.799/0.035、2.144/0.015)。结论老年稳定型心绞痛患者PCI术前血清Irisin、Preptin呈低表达,二者与患者PCI术后预后不良密切相关。
Objective To analyze the serum Irisin and Preptin levels before percutaneous coronary intervention(PCI)in elderly patients with stable angina pectoris and their relationship with the prognosis of patients after PCI.Methods A total of 96 elderly patients with stable angina pectoris who were admitted to the Affiliated Central Hospital of Shandong First Medical University from June 2019 to August 2020 were selected as the research group,and 96 healthy people who underwent physical examination during the same period were selected as the healthy control group.Serum Irisin and Preptin levels were detected in the two groups,and coronary Gensini scores were performed in the study group before PCI.The patients were followed up for 1 year after PCI,and the patients were divided into 86 patients with good prognosis and 10 patients with poor prognosis according to whether they had cardiovascular events.The correlation between serum Irisin,Preptin and Gensini score before PCI was analyzed,the factors affecting the prognosis of elderly patients with stable angina pectoris after PCI were analyzed by logistic regression,and the effect of serum Irisin and Preptin before PCI on the prognosis of elderly patients with stable angina pectoris after PCI was analyzed by ROC.Bad predictive value.Results The serum levels of Irisin and Preptin in the study group before PCI were lower than those in the healthy control group(t/P=21.655/<0.001,9.424/<0.001).The serum levels of Irisin and Preptin before PCI in the single-vessel disease subgroup,the double-vessel disease subgroup,and the three-vessel disease subgroup decreased sequentially(F/P=198.629/<0.001,44.409/<0.001).The pre-PCI serum Irisin and Preptin levels in the poor prognosis subgroup were lower than those in the good prognosis subgroup,and the Gensini score was higher than that in the good prognosis subgroup(t/P=8.963/<0.001,3.533/0.001,10.226/<0.001).Serum Irisin and Preptin levels were positively correlated with pre-PCI in elderly patients with stable angina pectoris(r/P=0.591/<0
作者
孙素清
周元丽
耿庆信
李莉
Sun Suqing;Zhou Yuanli;Geng Qingxin;Li Li(School of Clinical Medicine,Shandong First Medical University,Shandong Province,Jinan 250000,China;不详)
出处
《疑难病杂志》
CAS
2022年第3期221-225,共5页
Chinese Journal of Difficult and Complicated Cases
基金
山东省医药卫生科技发展计划项目(2019WS217)。
