摘要
目的:探讨我国中医药防治肺癌化疗后消化道反应的用药规律。方法:检索中国知网、万方、维普数据库自建库以来至2020年9月中医药防治肺癌化疗后消化道反应的文献,筛选后建立数据库,运用IBM SPSS Statistics 20.0、IBM SPSS Modeler 18.0进行数据挖掘,总结我国中医药防治肺癌化疗后消化道反应的用药规律。结果:(1)共纳入131篇文献共计245味中药进行数据挖掘;(2)使用频次较高的中药有黄芪、甘草、茯苓、白术、半夏、党参、麦冬、薏苡仁、陈皮、北沙参等;(3)所用中药以补虚药、化痰止咳平喘药、利水渗湿药、清热药、消食药为主,药味苦、甘并存,药性寒、温并用,归经涉及肝、肺、胃、脾、肾多个脏腑;(4)聚类分析得出7个核心中药组合,关联规则分析得出24个药对(组)。结论:通过对防治肺癌化疗后消化道反应的中药进行数据挖掘,能够发现潜在的中药组方规律,明确核心中药,有助于为后续消化道反应治疗药物的开发研究及现代临床实践提供一定参考。
Objective:To explore the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Methods:The literatures on prevention and treatment of gastrointestinal reaction after chemotherapy with Chinese medicine were searched from CNKI,Wanfang and VIP databases from the establishment of the database to September 2020.After screening,the database was established,and data mining was conducted by using IBM SPSS statistics 20.0 and IBM SPSS modeler 18.0 to summarize the medication rules of traditional Chinese medicine in the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer.Results:(1)A total of 131 literatures involving 245 traditional Chinese medicines were included for data mining;(2)High frequency drugs include Astragalus membranaceus,liquorice,Poria cocos,Atractylodes macrocephala,Pinellia ternata,Codonopsis pilosula,Ophiopogon japonicus,coix seed,Pericarpium Citri Reticulatae,Radix Glehniae etc;(3)The traditional Chinese medicine used is mainly tonic medicine,resolving phlegm and relieving cough and asthma medicine,diuresis and dampness medicine,heat clearing medicine and antiphlogistic medicine.The medicine tastes bitter and sweet,and has cold and warm properties.The meridian tropism involves the liver,lung,stomach,spleen and kidney;(4)Seven core TCM combinations were obtained by cluster analysis,and 24 drug pairs(groups)were obtained by association rule analysis.Conclusion:Through the data mining of traditional Chinese medicine for the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer,we can find out the potential rules of traditional Chinese medicine prescription,and clarify the core Chinese medicine,which is helpful to provide certain reference for the development and research of drugs for the treatment of gastrointestinal reaction and modern clinical practice.
作者
林月洁
罗钺
王璐瑶
张培彤
LIN Yue‐jie;LUO Yue;WANG Lu‐yao;ZHANG Pei‐tong(Guang’anmen Hospital,China Academy of Chinese Medicine Sciences,Beijing 100053,China)
出处
《海南医学院学报》
CAS
2022年第5期357-362,共6页
Journal of Hainan Medical University
基金
国家自然科学基金资助项目(81673797)。
关键词
肺癌
化疗
消化道反应
中药
用药规律
Lung cancer
Chemotherapy
Ggastrointestinal reaction
Traditional Chinese medicine
Medication rules
