摘要
目的:探讨Fibro Touch技术在诊断慢性乙型肝炎患者肝纤维化程度中的应用价值。方法:选取某院2018年10月~2019年3月收治的200例慢性乙型肝炎患者,所有患者均行Fibro Touch技术检查及肝组织活检,统计肝组织活检结果,并将肝组织活检结果作为诊断金标准,对比S_(0)~S_(4)分期肝纤维化患者Fibro Touch检测值(LSM值),分析肝纤维化与LSM值的相关性,明确LSM值对肝组织病理学纤维化分期整体诊断价值。结果:200例慢性乙型肝炎肝纤维化患者中,肝组织活检结果为:S_(0)期14例,占7.00%;S_(1)期46例,占23.00%;S_(2)期51例,占25.50%;S_(3)期54例,占27.00;S_(4)期35例,占17.50%;S_(0)~S_(4)分期肝纤维化患者LSM值组间对比,差异有统计学意义(P<0.05);随着患者纤维化程度不断加重,其LSM值呈递增趋势;在慢性乙型肝炎患者中,肝脏LSM值与肝纤维化程度呈正相关(r=0.774,P=0.000),即LSM值随着纤维程度增加呈递增趋势;经ROC曲线下面积(AUC)得出LSM值对慢性乙型肝炎患者肝组织病理学纤维化分期整体诊断价值好,其AUC=0.735,P<0.001,诊断敏感度、特异度分别为0.833,0.959。结论:Fibro Touch技术在诊断慢性乙型肝炎患者肝纤维化程度中具有较高应用价值,且具有简单快速、无创、安全等优势,值得临床推广。
Objective:To explore the application value of Fibro Touch technology in the diagnosis of liver fibrosis in patients with chronic hepatitis B.Methods:200 patients with chronic hepatitis B who were admitted to a hospital from October 2018 to March 2019 were selected.All patients underwent Fibro Touch technology examination and liver tissue biopsy.The liver tissue biopsy results were counted,the liver tissue biopsy results were taken as the gold standard for diagnosis,the Fibro Touch detection values(LSM value)of S_(0)~S_(4) stage liver fibrosis patients were compared,the correlation between liver fibrosis and LSM value was analyzed,and the overall diagnostic value of LSM value for liver histopathological fibrosis staging was clarified.Results:Among 200 patients with chronic hepatitis B liver fibrosis,liver biopsy results were:S_(0) stage 14 cases,accounting for 7.00%;S_(1) stage 46 cases,accounting for 23.00%;S_(2) stage 51 cases,accounting for 25.50%;S_(3) stage 54 Cases,accounting for 27.00%;S_(4) stage 35 cases,accounting for 17.50%.The difference in LSM values of S_(0)~S_(4) stage liver fibrosis patients was statistically significant among the groups(P<0.05);With increasing of fibrosis of patients,the LSM value were increasing.In patients with chronic hepatitis B,the liver LSM value was positively correlated with the degree of liver fibrosis(r=0.774,P=0.000),that was,the LSM value increased with the increasing of degree of fibrosis.The area under the ROC curve(AUC)showed that the LSM value was good for the overall diagnosis of liver histopathological fibrosis staging in patients with chronic hepatitis B(AUC=0.735,P<0.001).The diagnostic sensitivity and specificity were 0.833 and 0.959,respectively.Conclusion:Fibro Touch technology has high application value in the diagnosis of the degree of liver fibrosis in patients with chronic hepatitis B,and has the advantages of simple,fast,non-invasive and safety,which is worthy of clinical promotion.
作者
董小平
Dong Xiaoping(Sanmenxia Central Hospital,Sanmenxia 472000)
出处
《数理医药学杂志》
CAS
2022年第3期359-361,共3页
Journal of Mathematical Medicine
基金
三门峡市科学技术局文件(编号为:2017010303)。
