摘要
细胞焦亡(pyroptosis)是一种程序性的死亡方式,活化的天冬半胱氨酸酶-1(caspase-1)可以诱导焦亡的发生,并促进炎症因子IL-1β和IL-18等的释放,且焦亡广泛参与各种慢性疾病的进展,如动脉粥样硬化(atherosclerosis,AS)、2型糖尿病等。有研究表明,自噬的缺陷会刺激细胞焦亡,且会加快AS的进程。本文总结了近几年来有关细胞焦亡及其在AS发展中的作用研究进展,并探讨了细胞焦亡与自噬的相互关系是否可作为防治AS的新靶点。
Pyroptosis is different from other types of cell death in morphologically and mechanistically,and it is a type of cell death that relies on the inflammasome.Activated caspase-1 can induce pyroptosis,and cells secrete pro-inflammatory cytokines IL-1βand IL-18,which are widely involved in the progression of various chronic diseases,such as atherosclerosis and type 2 diabetes.Some studies have shown that defects in autophagy can stimulate pyroptosis and accelerate the process of atherosclerosis.This article summarizes the research progress of pyroptosis and its role in the development of atherosclerosis in recent years,and discusses whether the relationship between pyroptosis and autophagy can be used as a new target for the prevention and treatment of atherosclerosis.
作者
潘天琦
田华
姚树桐
PAN Tianqi;TIAN Hua;YAO Shutong(College of Basic Medical Sciences,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2022年第2期156-160,共5页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
国家自然科学基金(81800394,81570410)。
