摘要
目的:探讨柴胡桂枝汤加减联合干扰素治疗带状疱疹后遗神经痛的临床疗效及对视觉模拟评分(VAS)、睡眠质量的影响。方法:通过随机数字表法将2019年2月至2020年6月海南省安宁医院收治的110例带状疱疹后遗神经痛患者分为对照组和治疗组,每组55例。对照组患者给予干扰素治疗,治疗组患者在对照组的基础上联合柴胡桂枝汤加减治疗。观察两组患者治疗前后VAS评分、匹兹堡睡眠质量指数(PSQI)评分、皮肤病生活质量指数(DLQI)评分和中医证候评分,各血清指标[神经肽Y(NPY)、β-内啡肽(β-EP)、P物质(SP)和神经激肽-1(NK-1)]水平,并观察两组患者的临床疗效与不良反应发生情况。结果:与对照组的总有效率[85.45%(47/55)]比较,治疗组患者的总有效率明显更高,为98.18%(54/55),差异有统计学意义(χ^(2)=5.930,P=0.015)。治疗后,两组患者VAS评分、PSQI评分、DLQI评分和中医证候评分均较治疗前明显降低,且治疗组患者上述评分明显低于对照组,差异均有统计学意义(P<0.05)。与治疗前相比,两组患者治疗后NPY、SP和NK-1水平均降低,β-EP水平升高;与对照组治疗后比较,治疗组患者治疗后NPY、SP和NK-1水平明显更低,β-EP水平明显更高,差异均有统计学意义(P<0.05)。治疗组患者的不良反应发生率为3.64%(2/55),明显低于对照组的14.55%(8/55),差异有统计学意义(χ^(2)=3.960,P=0.047)。结论:针对带状疱疹后遗神经痛患者,采用柴胡桂枝汤加减联合干扰素治疗的疗效确切,不但能减轻患者的疼痛程度,还能提高睡眠质量和生活质量,改善症状,调节各类疼痛介质表达,且安全性较好。
OBJECTIVE: To probe into the clinical efficacy of Chaihu Guizhi decoction combined with interferon in the treatment of postherpetic neuralgia and its effects on visual analogue scale(VAS) score and sleep quality. METHODS: Totally 110 patients with postherpetic neuralgia admitted into Hainan Provincial Anning Hospital from Feb. 2019 to Jun. 2020 were extracted to be divided into the control group and the treatment group via the random number table, with 55 cases in each group. The control group was treated with interferon, while the treatment group received Chaihu Guizhi decoction on the basis of the control group. The VAS score, Pittsburgh sleep quality index(PSQI), Dermatology Life Quality Index(DLQI) and traditional Chinese medicine syndrome score, serum indicators [neuropeptide Y(NPY), β-endorphins(β-EP), substance P(SP) and neurokinin-1(NK-1)] before and after treatment were compared between two groups. Clinical efficacy and adverse drug reactions of two groups were analyzed. RESULTS: Compared with 85.45%(47/55) in the control group, the total effective rate in the treatment group was 98.18%(54/55), the difference was statistically significant(χ^(2)=5.930, P=0.015). After treatment, VAS score, PSQI score, DLQI score and TCM syndrome score in two groups were significantly lower than those before treatment, and the above scores in treatment group were significantly lower than those in control group, the differences were statistically significant(P<0.05). After treatment, the levels of NPY, SP and NK-1 decreased and β-EP increased in two groups compared with before treatment. Compared with the control group after treatment, the levels of NPY, SP and NK-1 in the treatment group were significantly lower and the levels of β-EP were significantly higher after treatment, with statistically significant difference(P<0.05). The incidence of adverse drug reactions in the treatment group was 3.64%(2/55), significantly lower than 14.55%(8/55) in the control group, the difference was statistically significant(χ^(2)=3.
作者
徐雪怡
黎顺成
韦日铺
杨进
梁潇
XU Xueyi;LI Shuncheng;WEI Ripu;YANG Jin;LIANG Xiao(Dept.of Medical Rehabilitation,Hainan Provincial Anning Hospital,Haikou 570206,China;College of Acumox and Tuina,Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)
出处
《中国医院用药评价与分析》
2022年第2期185-187,192,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
广西自然科学基金项目(No.2018GXNSFBA281198)。
