摘要
目的通过精神心理及生活质量状况调查分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与咽喉反流性疾病(laryngopharyngeal reflux disease,LPRD)的相关性。方法选取2016年9月~2020年8月以打鼾为主诉的235例患者为研究对象,进行多道睡眠图(PSG)监测并填写反流症状指数量表(reflux symptom index,RSI)、Epworth 嗜睡量表(ESS)、焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)和健康调查量表(SF-36),根据呼吸暂停低通气指数(AHI)及是否伴有LPRD分组,使用SPSS 22.0比较各组之间上述指标的差异。结果经PSG监测诊断为单纯打鼾组32例,轻度组38例,中度组32例,重度组133例,OSAHS伴LPRD 108例;OSAHS伴LPRD组在ESS、AHI、RSI、SAS、SDS上分值明显高于OSAHS不伴LPRD组,RSI与ESS、SAS、SDS评分明显正相关(r分别为0.143、0.225、0.164,P均<0.05);OSAHS伴LPRD组在SF-36各维度上分值均低于OSAHS不伴LPRD组,除一般健康状况(general health,GH)这一维度外,其余维度评分及躯体生理健康总评(physical component summary,PCS)和精神心理健康总评(mental component summary,MCS)的2个综合分数两组间差异均有统计学意义(P<0.05)。结论合并LPRD的OSAHS患者较单纯OSAHS患者有更为突出的精神心理异常和更严重的生活质量下降,可以使用质子泵抑制剂联合促胃肠动力药治疗LPRD,进而有效治疗OSAHS,并促进其身心健康提高生活质量。
OBJECTIVE To analyze the mental psychology status,quality of life in patients of obstructive sleep apnea hypopnea syndrome(OSAHS) with Laryngopharyngeal Reflux Disease(LPRD).METHODS A total of 235 patients with snoring from September 2016 to August 2020 were selected for polysomnography(PSG) and filling in the reflux symptom index(RSI),Epworth sleepiness scale(ESS),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and Health survey scale(SF-36 health survey scale,SF-36).The patients were divided into different groups according to apnea hypopnea index(AHI) and with or without LPRD.SPSS software(22.0) was used to compare the differences of the above-mentioned indexes among the different groups.RESULTS There were 32 cases in the simple snoring group,38 cases in the mild group,32 cases in the moderate group,133 cases in the severe group,and 108 cases of OSAHS with LPRD.The ESS,AHI,RSI,SAS and SDS scores in patients of OSAHS with LPRD group were significantly higher than those of OSAHS without LPRD group,and the RSI scores were significantly positively correlated with ESS,SAS and SDS scores(r=0.143,0.225,0.164,respectively,P<0.05).The scores in OSAHS with LPRD group were lower than those in OSAHS without LPRD group in all dimensions and 2 comprehensive scores of SF-36.Except for the score of general health status,the differences between the two groups were statistically significant(P<0.05).CONCLUSION Compared with simple OSAHS patients,OSAHS patients with LPRD have more prominent psychosocial abnormalities and more serious decline in quality of life.Therefore,proton pump inhibitors combined with gastrointestinal motility drugs could be considered for the treatment of LPRD,so as to OSAHS,and can also promote their physical and mental health and improve their quality of life.
作者
张初琴
陈波蓓
项海杰
陈如如
伊松
ZHANG Chuqin;CHEN Bobei;XIANG Haijie;CHEN Ruru;YI Song(Department of Otolaryngology,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325027,China;Department of Orthodontic,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,Zhejiang,325027,China)
出处
《中国耳鼻咽喉头颈外科》
CSCD
2022年第1期15-19,共5页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
温州市科技局资助项目(Y2020028)
台州市科技局资助项目(20ywb83)。
关键词
睡眠呼吸暂停
阻塞性
焦虑
抑郁
生活质量
咽喉反流性疾病
Sleep Apnea,Obstructive
Anxiety
Depression
Quality of Life
laryngopharyngeal reflux disease
