摘要
目的探讨血清共刺激分子B7同源体4(B7-H4)、组织多肽特异性抗原(TPS)水平与肺腺癌患者胸腔镜根治术后复发的相关性。方法选择2018年2月—2019年2月本院拟行胸腔镜根治术治疗的97例肺腺癌患者作为研究对象,入院时测定实验室指标,术后随访2年,统计2年复发情况,比较复发与未复发患者基线资料和实验室指标,重点分析血清B7-H4、TPS水平与肺腺癌患者胸腔镜根治术后复发的相关性。结果以复发作为终点时间,全部患者随访时间为3-24个月,平均(12.11±3.02)个月;97例患者,随访期间累计30例复发,复发率为30.93%;复发患者血清糖类抗原125(CA125)、糖类抗原(CA19-9)、B7-H4、TPS水平高于未复发患者(P<0.05),组间其他资料比较差异无统计学意义(P>0.05);经Logistic回归分析结果显示,肺腺癌患者胸腔镜根治术前血清CA125、CA19-9、B7-H4、TPS与术后复发有关,血清CA125、CA19-9、B7-H4、TPS水平过表达可能是肺腺癌患者胸腔镜根治术后复发的风险因子(OR>1,P<0.05);绘制ROC曲线发现,肺腺癌患者胸腔镜根治术前血清B7-H4、TPS单独及联合预测术后复发的AUC分别为0.890、0.886、0.935,AUC均>0.85,均有一定预测价值,且以联合预测价值最佳。结论肺腺癌患者胸腔镜根治术前测定血清B7-H4、TPS水平,若呈异常过表达,可能提示术后2年内存在较高复发风险,可将二者联合用于预测患者术后复发风险。
Objective To investigate the correlation between serum B7 homologous body 4(B7-H4)and tissue polypeptide-specific antigen(TPS)levels and recurrence of patients with lung adenocarcinoma after thoracoscopic radical resection.Methods 97 patients with lung adenocarcinoma who will underwent thoracoscopic radical resection in Zhengzhou Orthopedic Hospital from February 2018 to February 2019 were prospectively selected as the research subjects,laboratory indexes were measured at their admission,the patients were followed up for 2 years after operation,the recurrence within 2 years were counted.The baseline data and laboratory indexes of recurrent and non-recurrent patients were compared.The correlation between serum B7-H4,TPS levels and recurrence of patients with lung adenocarcinoma after thoracoscopic radical resection was mainly analyzed.Results The time of recurrence was taken as the terminal point,all patients were followed up for 3~24 months,the average follow-up time was(12.11±3.02)months.Among the 97 patients,30 cases recurred during the follow-up period,and the recurrence rate was 30.93%.The levels of serum carbohydrate antigen 125(CA125),carbohydrate antigen(CA19-9),B7-H4 and TPS in patients with recurrence were higher than those without recurrence(P<0.05),there were no statistical significant difference in the comparison of other data between the two groups(P>0.05).The results of Logistic regression analysis showed that serum CA125,CA19-9,B7-H4 and TPS levels in patients with lung adenocarcinoma before thoracoscopic radical resection were associated with postoperative recurrence,the overexpression of serum CA125,CA19-9,B7-H4 and TPS levels might be the risk factors of recurrence of patients with lung adenocarcinoma after thoracoscopic radical resection(OR>1,P<0.05).The ROC curve was drawn and showed that AUC of serum B7-H4 and TPS in patients with lung adenocarcinoma before thoracoscopic radical resection alone and in combination in predicting the postoperative recurrence were 0.890,0.886 and 0.935,respectiv
作者
朱正帅
Zhu Zhengshuai(Department of thoracic surgery,Nanyang central hospital,Nanyang,Henan,473000,China.)
出处
《齐齐哈尔医学院学报》
2022年第2期121-125,共5页
Journal of Qiqihar Medical University
关键词
肺腺癌
胸腔镜根治术
复发
共刺激分子B7同源体4
组织多肽特异性抗原
Lung adenocarcinoma
Thoracoscopic radical resection
Recurrence
B7 homologous body 4
Tissue polypeptide-specific antigen
