摘要
目的探讨盐酸羟甲唑啉喷雾剂在慢性鼻窦炎患者中的临床效果及对炎性因子的影响。方法选择2019年6月—2020年6月慢性鼻窦炎患者136例作为研究对象,采用随机数表法分为两组,各68例。对照组采用克拉霉素联合标准桃金娘油肠溶胶囊,观察组给予克拉霉素联合盐酸羟甲唑啉喷雾剂治疗,两组均治疗4周,疗程后完成12个月随访。比较两组嗅觉功能、炎性因子、安全性及复发率。结果观察组用药后4周嗅觉功能Ⅰ级病例为61.76%,多于对照组的39.71%,Ⅱ级、Ⅲ级病例分别为33.82%和4.41%,少于对照组的17.65%和42.65%,差异有统计学意义(Z=27.843,P<0.05);观察组治疗后4周肿瘤坏死因子-α(TNF-α)(1.32±0.16)ng/mL、白细胞介素-6(IL-6)(26.31±2.59)pg/mL、白细胞介素-8(IL-8)(253.98±14.38)ng/mL、白细胞介素-1β(IL-1β)(27.31±2.69)pg/mL水平均低于对照组,差异有统计学意义(P<0.05);两组用药期间恶心呕吐、皮疹、肝肾异常总发生率分别为5.88%和2.94%,两组比较,差异无统计意义(χ^(2)=0.174,P=0.676);观察组疗程后8、12个月复发率分别为1.47%和2.94%,低于对照组的11.76%和13.24%,差异有统计学意义(χ^(2)=4.284、4.479,P=0.038、0.034)。结论盐酸羟甲唑啉喷雾剂用于慢性鼻窦炎患者中有助于改善患者嗅觉功能,可降低患者炎性因子水平,能降低远期复发率,且药物安全性较高。
Objective To investigate the clinical effect of oxymetazoline hydrochloride spray in patients with chronic sinusitis and its influence on inflammatory factors.Methods 136 patients with chronic sinusitis from June 2019 to June 2020 were selected as subjects.Random number table method was divided into two groups,with 68 cases in each group.The control group was treated with clarithromycin combined with standard myrtle oil enteric-coated capsules,and the observation group was treated with clarithromycin combined with oxymetazoline hydrochloride spray.Both groups were treated for 4 weeks,and a 12-month follow-up was completed after the course of treatment.The olfactory function,inflammatory factors,safety and recurrence rate of the two groups were compared.Results The number of patients with gradeⅠolfactory function in the observation group was 61.76%more than 39.71%in the control group 4 weeks after treatment,and the number of gradeⅡand gradeⅢcases were 33.82%and 4.41%,respectively,which were less than 17.65%and 42.65%of the control group,and the difference was statistically significant(Z=27.843,P<0.05).Tumor necrosis factor 4 weeks after treatment in the observation group-α(TNF-α)(1.32±0.16)ng/mL,interleukin-6(IL-6)(26.31±2.59)pg/mL,interleukin-8(IL-8)(253.98±14.38)ng/mL,interleukin-1β(IL-1β)(27.31±2.69)pg/mL were lower than that in the control group,and the difference was statistically significant(P<0.05).The total incidences of nausea and vomiting,skin rash,liver and kidney abnormalities in the two groups were 5.88%and 2.94%,respectively,compared with the two groups,the difference was not statistically significant(χ^(2)=0.174,P=0.676).The recurrence rates of the observation group at 8 and 12 months after treatment were 1.47%and 2.94%,respectively,lower than the control group 11.76%and 13.24%,and the difference was statistically significant(χ^(2)=4.284,4.479,P=0.038,0.034).Conclusion The use of oxymetazoline hydrochloride spray in patients with chronic sinusitis can help improve the patient's olfac
作者
张学勇
江安世
刘振华
ZHANG Xueyong;JIANG Anshi;LIU Zhenhua(Department of Otorhinolaryngology Head and Neck Surgery,Jimo District People's Hospital,Qingdao,Shandong Province,266200 China)
出处
《系统医学》
2022年第1期63-67,共5页
Systems Medicine
关键词
盐酸羟甲唑啉喷雾剂
慢性鼻窦炎
嗅觉功能
炎性因子
复发率
安全性
Oxymetazoline hydrochloride spray
Chronic sinusitis
Olfactory function
Inflammatory factors
Recurrence rate
Safety
