摘要
近年来,五加科药用植物由于其广泛的药理作用和保健功能,引起人们的广泛关注。虽然对其药理作用的相关研究众多,但是揭示其与肠道菌群相关性的研究相对较少,并且存在研究不够透彻、单体成分研究不足的现象,从而造成人们对其药理作用与肠道菌群之间的关系缺乏系统性的认识。以五加科药用植物(中药),主要是人参、三七为中心,回顾其历代研究、功效、活性成分及药理作用,总结其提取物及皂苷、多糖等单体成分对肠道菌群的调节作用,并将该调节作用与相关药理作用进行关联,旨在揭示人参、三七调节身体机能、促进人体健康的机制,为中药与肠道菌群的相关研究提供新的认识,提示五加科植物具有开发成新型益生元的潜力。
Recently, the plants from Araliaceae have attracted extensive attention due to their extensive pharmacological effects and healthy functions. Although there were many studies on their pharmacological effects, only a few studies revealed the relationship between its pharmacological effects and gut microbiota. Simutaneously, there were still some problems, such as insufficient thorough research as well as a lack of single component research, which resulting in a lack of systematic understanding of the relationship between their pharmacological effects and gut microbiota. Therefore, this review focuses on the medicinal plants(traditional Chinese medicine) from Araliaceae, mainly Renshen(Ginseng Radix et Rhizoma) and Sanqi(Notoginseng Radix et Rhizoma), reviews their past-present research, efficacy, active compounds and pharmacological effects, summarizes the regulatory effects of their extracts,saponins, polysaccharides and other monomer components on gut microbiota, and connects this regulatory effects with related pharmacological effects, aiming to reveal the mechanisms of Ginseng Radix et Rhizoma and Notoginseng Radix et Rhizoma on regulating body function and promoting human health. All of these suggested that the plants from Araliaceae have the potential to be developed into new prebiotics.
作者
杨娅楠
张芳
吴崇明
YANG Ya-nan;ZHANG Fang;WU Chong-ming(Pharmacology and Toxicology Research Center,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第1期308-316,共9页
Chinese Traditional and Herbal Drugs
关键词
五加科
人参
三七
肠道菌群
益生元
Araliaceae
Ginseng Radix et Rhizoma
Notoginseng Radix et Rhizoma
gut microbiota
prebiotics
