摘要
目的研究妊娠期糖尿病患者平均血小板体积(MPV)和血小板平均分布宽度(PDW)变化趋势及其与不良妊娠结局的关联。方法分析并比较选择于2020年1—12月86例妊娠期糖尿病产妇(GDM组)、80例妊娠糖耐量受损产妇(GIGT组)及102名正常产妇组的MPV和PDW差异;比较GDM组的MPV和PDW水平在孕前、中、晚期的变化趋势;分析3组MPV和PDW水平与不良母婴妊娠结局、新生儿Apgar评分及出生体质量的相关性。结果GDM组孕晚期的MPV和PDW水平均高于GIGT组和正常产妇组。Logistic回归显示,孕早期MPV、孕晚期MPV、孕晚期PDW为不良妊娠结局的危险因素。ROC曲线显示,孕晚期MPV(AUC=0.667,P<0.001)和孕晚期PDW(AUC=0.628,P=0.001)有一定预测能力。孕晚期MPV和PDW水平与出生体质量呈正相关(r=0.361、0.325,P<0.05)。3组5 min Apgar评分差异无统计学意义(P>0.05),GDM组出生体质量高于正常产妇组,差异有统计学意义(P<0.05),与GIGT组差异无统计学意义(P>0.05),巨大儿发生率高于正常产妇组,差异有统计学意义(P<0.05)。结论妊娠期糖尿病患者MPV和PDW水平是不良妊娠结局的危险因素,可能有助于预测不良妊娠结局。
Objective To study the change trend of mean platelet volume(MPV) and mean platelet distribution width(PDW) of patients with gestational diabetes and their relationship with adverse pregnancy outcomes.Methods To analyze and compare the differences of MPV and PDW among 86 women with gestational diabetes(GDM group),80 women with impaired gestational glucose tolerance(GIGT group) and 102 normal women from January to December 2020.Compared the change trends of MPV and PDW levels in the GDM group before,during and after pregnancy.The correlation between MPV and PDW levels in the three groups and adverse maternal and infant pregnancy outcomes,neonatal Apgar score and birth weight were analyzed.Results The levels of MPV and PDW in the third trimester of pregnancy in the GDM group were higher than those in the GIGT group and normal parturient group.Logistic regression showed that MPV in the first trimester,MPV in the third trimester,and PDW in the third trimester were risk factors for adverse pregnancy outcomes.The ROC curve shows that MPV in the third trimester(AUC=0.667,P<0.001) and PDW in the third trimester(AUG=0.628,P=0.001) had a certain predictive ability.The levels of MPV and PDW in the third trimester of pregnancy were positively correlated with birth weight(r=0.361,0.325,P<0.05).There was no significant difference in Apgar score at 5 min between the three groups(P>0.05),the birth weight of GDM group was higher than that of normal parturient group,the difference was statistically significant(P<0.05),but there was no significant difference between GDM group and GIGT group(P>0.05),and the incidence of macrosomia was higher than that of normal parturient group,the difference was statistically significant(P<0.05).Conclusion MPV and PDW levels in patients with gestational diabetes mellitus are risk factors for adverse pregnancy outcomes,and may help predict adverse pregnancy outcomes.
作者
张茹
张微微
杨苏容
ZHANG Ru;ZHANG Weiwei;YANG Surong(Department of Obstetrics and Gynecology,Fuyong People's Hospital of Bao'an District,Shenzhen,Guangdong Province,518103 China;Department of Gynecology,Xintian Community Health Service Center,Fuyong People's Hospital of Bao'an District,Shenzhen,Guangdong Province,518103 China;Fuyong People's Hospital of Bao'an District Qiaotou Shekang Department of Gynecology,Shenzhen,Guangdong Province,518103 China)
出处
《世界复合医学》
2021年第12期28-31,共4页
World Journal of Complex Medicine
基金
妊娠期糖尿病患者MPV和PDW的变化以及对妊娠结局的影响研究(2018JD198)。
关键词
妊娠期糖尿病
平均血小板体积
血小板平均分布宽度
不良妊娠结局
Gestational diabetes
Average platelet volume
Average platelet distribution width
Adverse pregnancy outcome
