摘要
报告1例幼年隆突性皮肤纤维肉瘤。患儿男,8岁。左侧腹股沟皮肤红色结节5个月。皮肤科检查:左侧腹股沟皮肤见一花生米大的半球形粉红色结节,表面光滑,境界清楚,结节质中等,与皮肤粘连,浸润感明显。皮损组织病理检查:表皮基本正常,真皮有增生的梭形细胞组成的细胞团块,部分梭形细胞呈特征性席纹状排列,未见明显细胞异形及核分裂象。免疫组化:增殖核抗原(Ki-67)(5%+),CD34(+),S-100蛋白(-)。分子生物学检测:COL1A1-PDGFB融合基因比例70%。诊断:隆突性皮肤纤维肉瘤。治疗上予扩大切除术辅以术后放疗,随访无复发。
A case of juvenile dermatofibrosarcoma protuberans is reported.An 8-year-old boy presented with a red nodule on his left groin for 5 months.Physical examination revealed a pink,hemispherical,well-defined,peanut-sized nodule with a moderate texture,a smooth surface,adhesion to skin,obvious infiltration,and no obvious tenderness and ulceration.Histopatho-logical examination showed generally normal epidermis.Massive spindle cells were found in the dermis,some of which were arranged in a characteristic storiform pattern.No obvious cell atypia or mitosis were found.Immunohistochemistry staining:proliferating nuclear antigen(Ki-67)(5%+),CD34(+),S-100(-).Molecular biological detection:COL1A1-PDGFB fusion gene rate was 70%.The diagnosis of dermatofibrosarcoma protuberans was made.Wide local excision and postoperative radiotherapy were performed.No recurrence was found during the follow-up so far.
作者
彭光玲
喻敏
陈靓
PENG Guang-ling;YU Min;CHEN Liang(Department of Dermatology,the Fifth People's Hospital of Chongqing,Chongqing 400016,China)
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2022年第3期156-158,共3页
Journal of Clinical Dermatology
关键词
皮肤纤维肉瘤
隆突性
dermatofibrosarcoma
protuberans
