摘要
目的观察对冠心病心绞痛患者应用氯吡格雷联合阿托伐他汀进行治疗的效果。方法86例冠心病心绞痛患者,随机分为对照组与观察组,每组43例。对照组给予常规治疗,观察组在对照组基础上给予氯吡格雷+阿托伐他汀治疗。对比两组的治疗效果、血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平、心功能指标[心排出量(CO)、心脏指数(CI)、左室射血分数(LVEF)]及心绞痛改善效果。结果观察组治疗总有效率95.35%显著高于对照组的76.74%,差异有统计学意义(P<0.05)。观察组治疗后的TC(4.25±0.39)mmol/L、TG(1.91±0.17)mmol/L及LDL-C(3.01±0.24)mmol/L低于对照组的(5.63±0.74)、(2.60±0.35)、(3.95±0.58)mmol/L,HDL-C(1.97±0.56)mmol/L高于对照组的(1.28±0.41)mmol/L,差异有统计学意义(P<0.05)。观察组治疗后的CO、CI、LVEF均高于对照组,心绞痛发作频次少于对照组,心绞痛持续时间短于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷联合阿托伐他汀可有效改善冠心病心绞痛患者的血脂水平,增强其心功能的同时,大大缩短心绞痛的持续时间,减少发作次数,疗效显著。
Objective To observe the effect of clopidogrel combined with atorvastatin on angina pectoris of coronary heart disease.Methods A total of 86 patients with angina pectoris of coronary heart disease were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with clopidogrel combined with atorvastatin on the basis of the control group.Both groups were compared in terms of therapeutic effect,blood lipids indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),highdensity lipoprotein cholesterol(HDL-C)]levels,heart function indicators[cardiac output(CO),cardiac index(CI),left ventricular ejection fraction(LVEF)]and angina pectoris improvement.Results The total effective rate 95.35% in the observation group was significantly higher than 76.74% in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had TC of(4.25±0.39)mmol/L,TG of(1.91±0.17)mmol/L and LDL-C of(3.01±0.24)mmol/L,which were lower than(5.63±0.74),(2.60±0.35),(3.95±0.58)mmol/L of the control group;the observation group had higher HDL-C of(1.97±0.56)mmol/L than(1.28±0.41)mmol/L of the control group.All the difference was statistically significant(P<0.05).After treatment,the CO,CI and LVEF of the observation group were higher than those of the control group,the frequency of angina pectoris was lower than that of the control group,and the duration of angina pectoris was shorter than that of the control group.All the differences were statistically significant(P<0.05).Conclusion The combination of clopidogrel and atorvastatin has significant efficacy on patients with angina pectoris of coronary heart disease,and can effectively improve the blood lipid level of patients with coronary heart disease and angina pectoris,enhance their cardiac function,greatly shorten the duration of angina pectoris,and reduce the number of attacks.
作者
于庆伟
YU Qingwei(Yingkou Huajun Hospital,Yingkou 115007,China)
出处
《中国现代药物应用》
2022年第4期141-143,共3页
Chinese Journal of Modern Drug Application
关键词
冠心病
心绞痛
氯吡格雷
阿托伐他汀
Angina pectoris
Coronary heart disease
Clopidogrel
Atorvastatin
