摘要
目的探究小儿肺炎合并心力衰竭(心衰)急诊治疗的临床效果。方法86例肺炎合并心衰急诊患儿,依据随机数字表法分为对照组和观察组,各43例。对照组采用常规急诊治疗,观察组采用常规急诊治疗+多巴胺+酚妥拉明治疗。比较两组患儿治疗效果、病情稳定时间、治疗前后心肌功能损伤指标、不良反应发生情况。结果观察组患儿治疗总有效率97.67%高于对照组的83.72%,差异具有统计学意义(P<0.05)。观察组患儿肺啰音消失时间(4.18±1.25)d、喘息消失时间(3.49±0.96)d、心率稳定时间(2.04±0.77)d、呼吸稳定时间(2.16±0.69)d均短于对照组的(5.29±1.66)、(5.20±1.88)、(4.42±1.38)、(4.03±1.13)d,差异均具有统计学意义(P<0.05)。治疗后,观察组患儿肌酸激酶(CK)(109.94±10.43)U/L、乳酸脱氢酶(LDH)(117.03±12.38)U/L、肌酸激酶同工酶(CK-MB)(34.70±3.19)U/L均低于对照组的(124.81±11.32)、(132.52±10.29)、(41.85±3.49)U/L,差异均具有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论对小儿肺炎合并心衰急诊治疗中应用多巴胺+酚妥拉明,可提升治疗效果、缩短病程、降低患儿心肌损伤,且治疗安全性理想。
Objective To investigate the clinical effect of emergency treatment for pneumonia complicated with heart failure.Methods A total of 86 cases of infantile pneumonia complicated with heart failure in emergency department were divided into control group and observation group according to random numerical table,with 43 cases in each group.The control group received conventional emergency treatment,while the observation group received conventional emergency treatment+dopamine+phentolamine treatment.The therapeutic effect,stable time,myocardial function injury indexes before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 97.67% of the observation group was higher than 83.72% of the control group,and the difference was statistically significant(P<0.05).The disappearance time of lung rales(4.18±1.25)d,disappearance time of wheezing(3.49±0.96)d,stable time of heart rate(2.04±0.77)d and stable time of respiration(2.16±0.69)d in the observation group were all shorter than(5.29±1.66),(5.20±1.88),(4.42±1.38),and(4.03±1.13)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the creatine kinase(CK)(109.94±10.43)U/L,lactate dehydrogenase(LDH)(117.03±12.38)U/L,isoenzyme(CK-MB)(34.70±3.19)U/L in observation group was lower than(124.81±11.32),(132.52±10.29),(41.85±3.49)U/L in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of dopamine and phentolamine in the emergency treatment of infantile pneumonia complicated with heart failure can improve the therapeutic effect,shorten the course of disease,reduce myocardial injury in children,and the treatment safety is ideal.
作者
教野
JIAO Ye(Department of Pediatrics,People’s Hospital of Shenyang Economic and Technological Development Zone,Shenyang 110000,China)
出处
《中国现代药物应用》
2022年第4期4-6,共3页
Chinese Journal of Modern Drug Application
关键词
小儿肺炎
心力衰竭
急诊治疗
多巴胺
酚妥拉明
Infantile pneumonia
Heart failure
Emergency treatment
Dopamine
Phentolamine
