摘要
CD99L2(CD99 antigen-like 2)基因位于染色体Xq28,编码高度保守、广泛表达的糖基化跨膜蛋白。自2003年首次报道以来,CD99L2蛋白被认为是一种重要的黏附分子,在炎症反应、白细胞渗出、淋巴瘤中起重要作用。但是,近年越来越多研究发现该基因与孤独症谱系障碍、脑性瘫痪、癫痫等神经系统疾病密切相关,但具体机制仍不清楚,该基因功能至今未明确。该文就CD99L2基因的研究进展进行综述。
CD99L2(CD99 antigen-like 2)gene is located at Xq28,which encodes a highly conserved and widely expressed glycosylated transmembrane protein.Since it was first reported in 2003,CD99L2 protein has been regarded as an important adhesion molecule,which plays an important role in inflammation,leukocyte exudation,and lymphoma.However,in recent years,more and more studies have found that this gene is closely related to neurological diseases such as autism spectrum disorder,cerebral palsy,and epilepsy,but the specific mechanism is still unclear,and the function of this gene is still unclear.This article reviews the research progress of CD99L2 gene.
作者
李栋(综述)
尹飞(审校)
王颖(审校)
Li Dong;Yin Fei;Wang Ying(Department of Pediatrics,Xiangya Hospital,Central South University,Changsha 410008,China)
出处
《国际儿科学杂志》
2022年第1期6-9,共4页
International Journal of Pediatrics
基金
国家自然科学基金(81801297)。
