摘要
目的:探讨五虎汤加味治疗儿童哮喘急性发作期的临床疗效。方法:将130例急性发作期哮喘儿童,随机分为观察组和对照组,每组65例,观察组给予五虎汤加味治疗,对照组给予盐酸丙卡特罗治疗,疗程1周,比较治疗前后患儿的主要症状(喘息、咳嗽、气促、胸闷)评分情况;次要症状(精神、流涕、口干、舌质、舌苔、大便等)评分情况,肺功能改善情况;免疫球蛋白(Ig)E表达、嗜酸性粒细胞(EOS)计数变化情况,血清白细胞介素(IL)因子(IL-5,IL-6,IL-8,IL-1β)水平变化。结果:该研究最终对126例患儿的数据进行统计分析。与本组治疗前比较,治疗后观察组和对照组主要症状(喘息、咳嗽、气促、胸闷),次要症状(精神、流涕、口干、舌质、舌苔、大便)评分、血清IL水平和IgE表达,EOS计数明显降低(P<0.05),肺功能指标明显升高(P<0.05);治疗后与对照组比较,观察组咳嗽症状与次要症状评分明显降低(P<0.05);IL-1β表达水平降低程度不及对照组(P<0.05)。肺功能指标,IgE表达,EOS计数改善情况与对照组等同。结论:五虎汤加味治疗儿童哮喘急性发作期痰热阻肺证能明显减轻哮喘患儿的临床症状,改善肺功能,降低IgE,IL-5,IL-6,IL-8,IL-1β表达水平和EOS计数,总体临床疗效优于或等同盐酸丙卡特罗。
Objective: To explore the clinical effect of modified Wuhutang in the treatment of children with acute asthma. Method: A total of 130 children with acute asthma were randomly divided into an observation group and a control group,with 65 cases in each group. The observation group was treated with modified Wuhutang and the control group was treated with procaterol hydrochloride for one week. The scores of primary symptoms(wheezing,cough,shortness of breath,and chest tightness)and secondary symptoms(mental status, runny nose, dry mouth, tongue texture, tongue coating, stool, etc.), lung functions,immunoglobulin E(IgE)expression,eosinophil(EOS)count,and serum inflammatory factors,including interleukin(IL)-5,IL-6,IL-8,and IL-1β in two groups before and after treatment were compared. Result:The data of 126 children were statistically analyzed. As revealed by the results,compared with the conditions before treatment,the scores of primary symptoms and secondary symptoms,serum levels of IL,IgE expression,and EOS count were both reduced in two groups(P<0.05),lung functions were increased in the two groups(P<0.05). Compared with the control group after treatment,the observation group showed decreased scores of cough and secondary symptoms(P<0.05),and insignificant decrease in IL-1β(P<0.05). The improvement in lung functions, IgE expression, and EOS count in observation group was equivalent to that in control group.Conclusion: Modified Wuhutang for treatment of acute asthma in children(phlegm-heat obstructing lung syndrome)can significantly relieve the clinical symptoms,improve lung functions,and reduce IgE,IL-5,IL-6,IL-8,IL-1β expression levels and EOS count,and its overall clinical efficacy is superior or equivalent to that of tprocaterol hydrochloride.
作者
于琳琳
王婧
叶智祺
陆容
景晓平
YU Lin-lin;WANG Jing;YE Zhi-qi;LU Rong;JING Xiao-ping(Children′s Hospital of Shanghai,Children′s Hospital of Shanghai Jiaotong University,Shanghai 200040,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第5期95-101,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
上海市科学技术委员会中医引导项目(19401931900)
上海市“科技创新行动计划”医学创新研究专项(21Y11921700)
上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-FWTX-3025]。
关键词
儿童哮喘
急性发作期
五虎汤加味
临床观察
childhood asthma
acute exacerbation
modified Wuhutang
clinical research
