摘要
目的探讨后循环缺血性头晕患者发生认知功能障碍与血管内皮功能、氧化应激和脑白质改变的相关性。方法选取2018年1月至2021年1月新疆维吾尔自治区人民医院收治的598例后循环缺血性头晕患者作为观察对象,根据是否发生认知功能障碍将其分为认知功能障碍组(121例)和非认知功能障碍组(477例)。采用年龄相关的脑白质改变(ARWMC)评分评估脑白质改变严重程度。比较两组血管内皮功能、氧化应激指标水平及ARWMC评分,并分析上述指标与认知功能障碍发生的相关性。结果认知功能障碍组内皮素-1(ET-1)、丙二醛(MDA)水平和ARWMC评分均高于非认知功能障碍组,降钙素基因相关肽(CGRP)、一氧化氮(NO)、超氧化物歧化酶(SOD)水平低于非认知功能障碍组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,患者ET-1、MDA水平及ARWMC评分与认知功能障碍发生呈正相关(rs>0,P<0.05),CGRP、NO及SOD水平与认知功能障碍发生呈负相关(rs<0,P<0.05)。结论后循环缺血性头晕患者认知功能障碍发生率高,与血管内皮功能、氧化应激和脑白质改变相关。临床上可以从减轻血管内皮损伤及氧化应激方面预防该病患者发生认知功能障碍,并且可对其进行脑白质改变评估,帮助早期识别认知功能障碍。
Objective To investigate the correlation of cognitive dysfunction with vascular endothelial function,oxidative stress,and white matter changes in patients with posterior circulation ischemia-induced dizziness.Methods A total of 598 patients with posterior circulation ischemia-induced dizziness in Xinjiang Uygur Autonomous Region People’s Hospital from January 2018 to January 2021 were selected as observation subjects.According to the occurrence of cognitive dysfunction,they were divided into cognitive dysfunction group(121 cases)and non-cognitive dysfunction group(477 cases).The age related white matter changes(ARWMC)score was used to assess the severity of white matter change.The levels of vascular endothelial function,oxidative stress index,and ARWMC score were compared between the two groups,and the correlation between these indexes and the occurrence of cognitive dysfunction was analyzed.Results The levels of endothelin-1(ET-1),malondialdehyde(MDA),and ARWMC score in the cognitive dysfunction group were higher than those in the non-cognitive dysfunction group,and the levels of calcitonin gene-related peptide(CGRP),nitric oxide(NO),and superoxide dismutase(SOD)were lower than those in non-cognitive dysfunction group,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that ET-1,MDA levels,and ARWMC score were positively correlated with the occurrence of cognitive dysfunction(rs>0,P<0.05),CGRP,NO,and SOD levels were negatively correlated with cognitive dysfunction(rs<0,P<0.05).Conclusion Patients with posterior circulation ischemia-induced dizziness have a high incidence of cognitive dysfunction,which is related to vascular endothelial function,oxidative stress,and white matter changes.Clinically,cognitive dysfunction in patients with this disease can be prevented from alleviating vascular endothelial injury and oxidative stress,and white matter change can be evaluated for patients to help early recognition of cognitive dysfunction.
作者
奥通沙·热合买提
杨丽娟
阿不都热合满·买买提
李红燕
Aotongsha·rehemaiti;YANG Lijuan;Abudureheman·mamati;LI Hongyan(Department of Neurology,Xinjiang Uygur Autonomous Region People’s Hospital,Xinjiang Uygur Autonomous Region,Urumqi830000,China;Department of Medical Record Quality,Xinjiang Uygur Autonomous Region People’s Hospital,Xinjiang Uygur Autonomous Region,Urumqi830000,China)
出处
《中国医药导报》
CAS
2022年第5期71-74,共4页
China Medical Herald
基金
新疆少数民族科技人才特殊培养计划科研项目(2019D03028)。
关键词
后循环缺血
头晕
认知功能障碍
血管内皮功能
氧化应激
脑白质改变
Posterior circulation ischemia
Dizziness
Cognitive dysfunction
Vascular endothelial function
Oxidative stress
White matter change
