摘要
目的探讨大连市社区中老年人群夜间睡眠时间与IGT发生风险的关系。方法选取2011年7~12月≥40岁大连市社区常住居民6358名开展基线调查,其中2645名完成3年随访且资料完整。分析不同夜间睡眠时间(<7、7~9、≥9 h)3年后IGT发生率,采用Logistic回归分析IGT的影响因素,并采用Cox比例风险回归模型评估不同夜间睡眠时间对IGT发生的影响。结果随访时新诊断IGT 396例(14.97%)。夜间睡眠时间<7、7~9、≥9 h的IGT发生率分别为18.25%、13.84%、15.57%(P<0.05)。Logistic回归分析显示,校正多种因素后,与夜间睡眠时间7~9 h比较,<7 h是IGT发生的危险因素(OR 1.378,95%CI 1.063~1.786,P<0.05)。Cox回归分析显示,<7 h的IGT发生风险显著增加(HR 1.303,95%CI 1.032~1.645,P<0.05)。按照年龄、BMI分层后,<7 h的超重/肥胖老年人群IGT发生风险进一步增加(HR 1.579,95%CI 1.032~2.414,P<0.05)。结论夜间睡眠时间不足是中老年人群IGT发生的危险因素,超重/肥胖的老年人群IGT发病风险进一步升高。
Objective To explore the association of nighttime sleep duration and incidence of impaired glucose tolerance(IGT)in middle-aged and elderly residents in communities in Dalian,China.Methods A cohort study was performed by recruiting 6358 middle-aged and elderly residents aged≥40 years old in communities from July to December 2011.2645 participants with normal blood glucose level in base-line were followed-up in 2014.The incidences of IGT by different nighttime sleep durations(<7 h,7~9 h and≥9 h)were calculated.Binary logistic regression models were built to assess the association between nighttime sleep durations(<7,7~9 and≥9 h)and IGT.Cox proportional hazards regression models were built to determine the effect of different nighttime sleep durations on IGT.Results In the 3-year follow-up in 2014,396(14.97%)participants were diagnosed as IGT.The incidences of newly diagnosed IGT in<7,7~9 and≥9 h groups were 18.25%,13.84%and 15.57%,respectively(P<0.05).Logistic regression analysis showed that compared with 7~9 h group,nighttime sleep duration<7 h was an independent risk factor of IGT(OR 1.378,95%CI 1.063~1.786,P<0.05)after adjusting relevant factors.Cox regression analysis demonstrated that<7 h increased the risk of IGT significantly(HR 1.303,95%CI 1.032~1.645,P<0.05).When stratified by age(40~60 years,middle-aged;≥60 years,elderly)and BMI(<24 kg/m;,underweight/normal weight;≥24 kg/m2,overweight/obesity),overweight/obesity elderly individuals with short sleepduration had an increased risk of IGT(HR 1.579,95%CI 1.032~2.414,P<0.05).Conclusion Short nighttime sleep duration was an independent risk factor of IGT in middle-aged and elderly residents,especially in overweight/obesity elderly individuals.
作者
赵薇
李欣宇
刘栩晗
罗兰
高政南
ZHAO Wei;LI Xinyu;LIU Xuhan(Department of Endocrinology,Dalian Municipal Central Hospital Affiliated to Daliaii Medical University,Dalian 116033,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2022年第1期52-56,共5页
Chinese Journal of Diabetes
基金
国家科技支撑项目计划资助(2013BAI09B13)。
关键词
中老年
睡眠时间
糖耐量减低
Middle-aged and elderly
Sleep duration
Impaired glucose tolerance
