摘要
胰腺移植和胰肾联合移植是治疗1型糖尿病和部分2型糖尿病及其并发症导致的肾衰竭的最佳治疗方法。胰腺移植的类型主要包括同期胰肾联合移植(SPK)、肾移植后胰腺移植(PAK)和单纯胰腺移植(PTA)。在所有的胰腺移植类型中,对移植胰腺的活组织检查(活检)仍然是明确诊断其排斥反应并与其他并发症进行鉴别的最佳方法。本文对移植胰腺活检的方法及其相关的研究进展、移植胰腺活检排斥反应诊断标准及其进展、移植胰腺主要的并发症及其病理学表现进行阐述,旨在为指导临床对上述并发症予以准确诊断,良好地保障移植胰腺和受者的长期存活提供参考。
Pancreas transplantation and pancreas-kidney transplantation are the optimal treatment for renal failure caused by type 1 diabetes mellitus,partial type 2 diabetes mellitus and their complications.Pancreas transplantation mainly includes simultaneous pancreas-kidney transplantation(SPK),pancreas transplantation after kidney transplantation(PAK)and pancreas transplantation alone(PTA).Among all types of pancreas transplantation,biopsy of pancreas allograft remains the best method for definitively diagnosing rejection and differentiate it from other complications.In this article,biopsy methods of pancreas allograft and related research progress,diagnostic criteria and research progress on rejection of pancreas allograft biopsy,and main complications and pathological manifestations of pancreas allograft were illustrated,aiming to provide reference for guiding the clinical diagnosis of the above mentioned complications and ensuring the long-term survival of pancreas allografts and recipients.
作者
郭晖
明长生
陈实
Guo Hui;Ming Changsheng;Chen Shi(Institute ofOrgan Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory ofOrgan Transplantation of Ministry of Education,Key Laboratory of Organ Transplantation of National Health Commission of China,KeyLaboratory of Organ Transplantation of Chinese Academy of Medical Sciences,Wuhan 430030,China)
出处
《器官移植》
CAS
CSCD
北大核心
2022年第2期176-186,共11页
Organ Transplantation
基金
中国医学科学院中央级公益性科研院所基本科研业务费专项资金(2019PT320014)。
