摘要
目的探讨血清脂联素水平对诊断急性脑梗死后认知功能障碍的价值。方法采用整群抽样法,于2018年10月至2020年4月选取新乡医学院第二附属医院神经内科收治的141例急性脑梗死患者作为研究对象,分为脑梗死后认知功能障碍组(n=73)及脑梗死后无认知功能障碍组(n=68)。于入院次日晨起时取患者外周静脉血,测定血清脂联素水平。采用美国国立卫生研究院卒中量表(NIHSS)、蒙特利尔认知评估量表(MoCA)分析患者的神经功能缺损及认知功能障碍。采用Pearson相关分析法分析急性脑梗死患者MoCA评分与血清脂联素水平的相关性。绘制受试者工作特征(ROC)曲线分析血清脂联素水平诊断脑梗死后认知功能障碍的价值。结果两组患者的基线资料、NIHSS评分比较,差异无统计学意义(P>0.05)。脑梗死后认知功能障碍组患者的MoCA评分、血清脂联素水平低于脑梗死后无认知功能障碍组,差异有统计学意义(P<0.01)。Pearson相关性分析显示,急性脑梗死患者的MoCA评分与血清脂联素水平呈正相关(r=0.411,P<0.05)。将脑梗死后认知功能障碍组患者按照脑梗死面积分为腔隙脑梗死组(n=51)、小面积脑梗死组(n=11)、大面积脑梗死组(n=11),3组患者的血清脂联素水平比较差异无统计学意义(P>0.05),但随着脑梗死面积扩大,血清脂联素水平呈现下降趋势。血清脂联素水平预测脑梗死后认知功能障碍的ROC曲线下面积为0.694(95%CI=0.607~0.781,P<0.05),敏感度和特异度分别为48.5%、84.9%。结论急性脑梗死认知功能障碍患者的脂联素水平较低,血清脂联素水平可以对脑梗死后认知功能障碍提供一定的诊断价值。
Objective To investigate the value of adiponectin level in the diagnosis of cognitive impairment in patients with acute cerebral infarction.Methods A total of 141 patients with acute cerebral infarction admitted to the Department of Neurology,the Second Affiliated Hospital of Xinxiang Medical College from October 2018 to April 2020 were enrolled by cluster sampling method.The patients were divided into cognitive impairment group(n=73)and non-cognitive impairment group(n=68)for comparative analysis.Peripheral venous blood was taken from the patient in the morning after admission,and serum adiponectin levels were measured for comparison between groups.The neurological deficit and cognitive impairment were analyzed by National Institutes of Health Stroke Scale(NIHSS)and Montreal Cognitive Assessment Scale(MoCA).Pearson correlation analysis was used to analyze the correlation between MoCA score and serum adiponectin level in patients with acute cerebral infarction.The receiver operating characteristic(ROC)curve was drawn to analyze the value of serum adiponectin level in the diagnosis of cognitive impairment after cerebral infarction.Results There was no significant difference in baseline data and NIHSS score between the two groups(P>0.05).The MoCA score and serum adiponectin level of patients with cognitive impairment after cerebral infarction were significantly lower than those without cognitive impairment after cerebral infarction(P<0.01).Pearson correlation analysis showed that there was a positive correlation between MoCA score and serum adiponectin level in patients with acute cerebral infarction(r=0.411,P<0.05).Patients with cognitive impairment after cerebral infarction were divided into lacunar cerebral infarction group(n=51),small area cerebral infarction group(n=11)and large area cerebral infarction group(n=11).There was no significant difference in the level of serum adiponectin among the three groups(P>0.05),but the level of serum adiponectin decreased with the expansion of cerebral infarction area.The a
作者
李谦
尚瑞华
李星
黄宇靖
程舒心
贾肖扬
杜爱玲
Li Qian;Shang Ruihua;Li Xing;Huang Yujing;Cheng Shuxin;Jia Xiaoyang;Du Ailing(Department of Neurology,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,China;Kidney Hospital,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,China;EICU,Henan Provincial People's Hospital,Zhengzhou 450000,China;Department of Neurology,the Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,China)
出处
《神经疾病与精神卫生》
2022年第2期106-111,共6页
Journal of Neuroscience and Mental Health
基金
2018年河南省医学科技攻关计划联合共建项目(2018020372)。
关键词
急性脑梗死
认知功能障碍
脂联素
Acute cerebral infarction
Cognition impairment
Adiponectin
