摘要
The newly developed technologies for profiling cellular heterogeneity have spurred a world-wide pursuit of singlecell analysis in the field of omics studies,investigating the genome,epigenome,transcriptome,proteome,metabolome,and their inherent interactions.Knowledge obtained through such analysis facilitates a deeper understanding of how underlying molecular and architectural changes alter cell behaviors,development,and disease processes.Genome-scale amplification of genomic DNAs or cDNAs from mRNAs transcribed in single cells allows for the measurement of genetic alterations and cell types at an unprecedented level.The emerging microchip-based tools for single-cell omics analysis further enable the evaluation of cellular omics with high throughput,improved sensitivity,and reduced cost.On the other hand,single-cell high-dimensional data obtained with high-throughput technologies also pose new challenges in bioinformatics to analyze,process,and make sense of the big data,in order to deliver new biological insights and knowledge.
基金
This work was partially supported by the National Natural Science Foundation of China(Grant Nos.31930022 and 12131020)
JST Moonshot R&D Project,Japan(Grant No.JPMJMS2021).
