摘要
目的探讨反复呼吸道感染(RRTI)儿童检测C反应蛋白(CRP)、T淋巴细胞亚群及免疫球蛋白在支原体肺炎诊断中的价值。方法选取2019年2月-2020年2月我院收治的100例RRTI儿童作为研究对象,根据诊断结果分为支原体肺炎组(n=78)和非支原体肺炎组(n=22),比较两组CRP、血清免疫球蛋白(IgG、IgM、IgA)及T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/8+)水平,并分析各指标对支原体肺炎的诊断价值。结果支原体肺炎组CRP为(28.50±5.59)mg/L,高于非支原体肺炎组的(22.04±5.37)mg/L,差异有统计学意义(P<0.05)。支原体肺炎组CD3+、CD4+以及CD4+/CD8+低于非支原体肺炎组,CD8+高于非支原体肺炎组,差异有统计学意义(P<0.05)。支原体肺炎组IgG高于非支原体肺炎组,IgA低于非支原体肺炎组,差异有统计学意义(P<0.05);两组IgM比较,差异无统计学意义(P>0.05)。联合检测灵敏度、特异度以及准确度均高于CRP、T淋巴细胞亚群以及免疫球蛋白单项检测,差异有统计学意义(P<0.05)。结论 CRP、T淋巴细胞亚群以及免疫球蛋白可作为RRTI儿童诊断支原体肺炎的重要指标,尤其是联合检测,能够有效提高支原体肺炎的检出率,具有较高的应用价值。
Objective To investigate the diagnostic value of C reactive protein(CRP),T lymphocyte subsets and immunoglobulin in children with recurrent respiratory tract infection(RRTI).Methods A total of 100 children with RRTI admitted to our hospital from February 2019 to February2020 were selected as the research objects.According to the diagnostic results,they were divided into mycoplasma pneumonia group( n=78) and nonmycoplasma pneumonia group(n=22).CRP,serum immunoglobulin(IgG,Ig M,Ig A) and T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/8+) levels in the two groups were compared,and the diagnostic value of each index for mycoplasma pneumonia was analyzed.Results The CRP of mycoplasma pneumonia group was(28.50±5.59) mg/L,which was higher than that(22.04±5.37) mg/L of non-mycoplasma pneumonia group,the difference was statistically significant(P <0.05).CD3+,CD4+and CD4+/CD8+in the mycoplasma pneumonia group were lower than those in the non-mycoplasma pneumonia group,and CD8+was higher than that in the non-mycoplasma pneumonia group,the difference was statistically significant( P<0.05).IgG in mycoplasma pneumonia group was higher than that in non-mycoplasma pneumonia group,IgA was lower than that in non-mycoplasma pneumonia group,the difference was statistically significant(P<0.05);while there was no significant difference in IgM between the two groups(P>0.05).The sensitivity,specificity and accuracy of combined detection were higher than those of CRP,T lymphocyte subsets and immunoglobulin single detection,and the difference was statistically significant(P <0.05).Conclusion CRP,T lymphocyte subsets and immunoglobulin can be used as important indicators for the diagnosis of mycoplasma pneumonia in RRTI children,especially the combined detection,which can effectively improve the detection rate of mycoplasma pneumonia and has high application value.
作者
赵津秀
ZHAO Jin-xiu(Department of Laboratory,Dongli District Dongli Hospital,Tianjin 300300,China)
出处
《医学信息》
2022年第4期174-176,共3页
Journal of Medical Information
关键词
反复呼吸道感染
C反应蛋白
T淋巴细胞亚群
免疫球蛋白
支原体肺炎
Recurrent respiratory tract infections
C-reactive protein
T lymphocyte subsets
Immunoglobulin
Mycoplasma pneumonia
