摘要
背景:近年来,镁离子良好的促进骨再生的作用已得到了实验和临床的广泛认可,含镁植入材料被广泛应用于骨再生,其促进骨再生的分子机制涉及骨环境中的多种细胞及细胞因子,但尚未完全明晰。目的:文章对镁离子促进骨再生的分子机制作一综述。方法:以“magnesium OR magnesium ion”“bone regeneration OR bone repair OR bone repairing OR osteogenesis OR osteanagenesis OR osteanaphysis OR osteoanagenesis”“mechanism OR molecular mechanism OR cell mechanism OR signal pathway OR signaling pathway OR endothelial cell OR vascular OR immune”为英文检索词检索PubMed数据库,以“镁、镁离子”“骨再生、骨修复、骨愈合、骨重建”“机制、分子机制、分子、细胞、信号通路、免疫、血管”为中文检索词检索中国知网和万方数据库。检索时间为建库至2021年12月,按照排除筛选标准纳入文献81篇,对纳入文献进行综述。结果与结论:①对于间充质干细胞,镁离子显著促进其增殖、迁移与黏附、成骨分化,尤其是既可以通过经典Wnt通路、MAPK/ERK通路等直接促其成骨分化,也可通过促进神经节细胞分泌CGRP、巨噬细胞分泌骨形态发生蛋白等细胞因子间接促进成骨分化。②对于成骨细胞,镁离子主要通过TRPM/PI3K信号通路促进其增殖、迁移与黏附、成骨活性,抑制其凋亡。③对于破骨细胞,镁离子主要通过核转录因子κB信号通路抑制破骨细胞形成及骨吸收活性。④镁离子可调节骨环境中的免疫反应,转化巨噬细胞表型,促进促成骨因子分泌,降低炎症因子分泌,降低炎症反应,同时促进血管内皮细胞增殖、迁移与黏附、成血管能力,促进血管生成。⑤镁离子促进骨再生的分子机制丰富,镁离子可通过对调节免疫反应与血管生成从而改善骨再生微环境的分子机制已成为近年来的研究热点,尤其是巨噬细胞的核转录因子κB通路和H型血管内皮细
BACKGROUND:In recent years,the role of magnesium ion in promoting bone regeneration has been widely recognized in experiment and clinic.Magnesium materials are widely used in bone regeneration.The molecular mechanism of magnesium promoting bone regeneration involves a variety of cells and cytokines in the local environment of bone,but it has not been fully clarified.OBJECTIVE:To review the molecular mechanism of magnesium ion on promoting bone regeneration.METHODS:The PubMed,CNKI and Wanfang databases were searched for relevant articles with the key words of“magnesium OR magnesium ion”,“bone regeneration OR bone repair OR bone repairing OR osteogenesis OR osteanagenesis OR osteanaphysis OR osteoanagenesis”,“mechanism OR molecular mechanism OR cell mechanism OR signal pathway OR signaling pathway OR endothelial cell OR vascular OR immune”in English and Chinese,respectively.The search time was from database establishment to December 2021.According to the exclusion and inclusion criteria,81 articles were included for review.RESULTS AND CONCLUSION:(1)For mesenchymal stem cells,magnesium ion can significantly promote their proliferation,migration,adhesion and osteogenic differentiation.In particular,it can not only directly promote their osteogenic differentiation through the classical Wnt pathway and MAPK/ERK pathway,but also indirectly promote their osteogenic differentiation by promoting the secretion of CGRP by ganglion cells and bone morphogenetic protein by macrophages.(2)For osteoblasts,magnesium ion mainly promotes their proliferation,migration,adhesion,osteogenic activity and inhibits their apoptosis through TRPM/PI3 K signaling pathway.(3)For osteoclasts,magnesium ion inhibits osteoclast formation and bone resorption mainly through nuclear factor-κB signaling pathway.(4)Magnesium ion regulates the immune response in the bone environment,transforms the phenotype of macrophages,promotes the secretion of bone factors,and reduces the secretion of inflammatory factors,thereby reducing the inflammator
作者
张竞心
刘林枫
张士文
林洁
Zhang Jingxin;Liu Linfeng;Zhang Shiwen;Lin Jie(State Key Laboratory of Oral Diseases/National Clinical Research Center for Oral Diseases/West China Hospital of Stomatology,Sichuan University,Chengdu 610041,Sichuan Province,China;State Key Laboratory of Oral Diseases/National Clinical Research Center for Oral Diseases/Department of Oral Implantology,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,Sichuan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2022年第33期5384-5392,共9页
Chinese Journal of Tissue Engineering Research
基金
四川大学横向课题(21H0441),项目负责人:林洁。
关键词
镁离子
镁
骨再生
骨修复
骨损伤
骨重建
分子机制
生物材料
组织工程
magnesium ion
magnesium
bone regeneration
bone repair
bone defect
bone remodeling
molecular mechanism
biomaterial
tissue engineering
