摘要
细胞珠蛋白是一种星状细胞特异性珠蛋白,最近因其与肝纤维化的关联而变成了一个热点蛋白。细胞珠蛋白在抑制非酒精性脂肪性肝炎(NASH)转化原发性肝癌中起着至关重要的作用。对国内外肿瘤研究的最新进展归纳总结发现,非可控性炎症在肿瘤发生、发展过程中发挥着相当重要的作用,同时“炎‑癌”转化的机制研究已成为肿瘤基础领域研究已成为新的前沿,以及有关“炎‑癌”转化的调控网络、分子机制及其信号通路已逐渐成为肿瘤预防和治疗的主要靶点。本篇综述主要概述了细胞珠蛋白的在肝脏中发挥潜在的功能包括氧化应激和信号通路传导,同时深入探讨了细胞珠蛋白抑制NASH向原发性肝癌转化主要体现在灭活肝星状细胞、增加脂肪转运和抵抗氧化应激三个方面,通过对“炎‑癌”转化的研究为原发性肝癌的预防、诊断和治疗找到新的突破口。
Cytoglobin(GYGB),a stellate cell⁃specific globin,has recently become a hotspot protein due to its association with liver fibrosis.The control of inflammation in tumor occurrence and development plays a quite important role in the process,and the transformation of“inflammation⁃cancer”mechanism research in the field of cancer basic research has become a new frontier,and the transformation of“inflammation⁃cancer”regulation network,molecular mechanism and signal pathway has gradually become the main target of tumor prevention and treatment.This review mainly summarizes the potential functions of globulin in the liver,including oxidative stress and signaling pathway transduction,and further discusses the inhibition of CYGB in the transformation from non⁃alcoholic steatohepatitis to primary liver cancer in three aspects:inactivation of hepatic stellate cells,increase of fat transport and resistance to oxidative stress.The study of“inflammation⁃cancer”transformation will provide a new breakthrough for the prevention,diagnosis and treatment of primary liver cancer.
作者
白瑜
黄峰
晁旭
Bai Yu;Huang Feng;Chao Xu(Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,Shaanxi,China;Department of Pathology,Basic Medical College,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;Department of Biochemistry,Basic Medical College,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China)
出处
《肿瘤代谢与营养电子杂志》
2022年第1期112-116,共5页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
国家自然科学基金项目(81774132)
陕西中医药大学学科创新团队项目(2019‑YS05)。
关键词
细胞珠蛋白
肝星状细胞
脂肪转运
抗氧化应激
Cytoglobin
Liver star cells
Increased fat transport
Resistance to oxidative stress
