摘要
目的探讨补脾益肾通络中药联合甲钴胺治疗糖尿病周围神经病变(DPN)患者的疗效。方法选取2019年3—11月于辽宁中医药大学附属第三医院综合病房治疗的DPN患者72例作为研究对象,随机分为甲钴胺组与联合组,各36例。对72例患者在采取饮食运动指导基础上联合降糖、稳定斑块、抗血小板聚集类药物治疗。甲钴胺组患者在上述治疗基础上加用甲钴胺治疗,联合组患者在甲钴胺组治疗基础上采用自拟补脾益肾通络汤。比较两组患者治疗前后肢体麻木刺痛、肢体末端感觉异常、腰膝酸软、少气懒言积分,多伦多临床评分系统(TCSS)评分,震动感觉阈值(VPT),下肢神经传导速度。结果治疗后,甲钴胺组及联合组肢体麻木刺痛、肢体末端感觉异常、腰膝酸软、少气懒言积分,TCSS评分,VPT较治疗前降低,且联合组低于甲钴胺组,差异有统计学意义(P<0.05);治疗后,甲钴胺组及联合组胫神经、腓总神经、腓浅神经、腓肠神经传导速度较治疗前增加,且联合组高于甲钴胺组,差异有统计学意义(P<0.05)。结论自拟补脾益肾通络汤联合甲钴胺可通过抑制脂质过氧化形成、延缓血管平滑肌生成、促胰岛素分泌、改善神经内膜血液循环等方式,改善DPN患者麻木刺痛、肢体末端感觉异常等症状,修复肢体运动及感觉神经功能。
Objective To explore the efficacy of Chinese medicinal for invigorating the spleen, kidney and collaterals combined with mecobalamin in the treatment of diabetic collateral disease. Methods A total of 72 patients with DKD admitted to the Comprehensive Internal Medicine ward of The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 2019 to November 2019 were selected as the research objects and were randomly divided into a methylcobalamin group, a combination therapy group, with 36 cases in each group. A total 72 patients were treated with anti-diabetic, plaque stabilizing and anti-platelet aggregation drugs on the basis of dietary exercise guidance. The patients in the mecobalamin group were treated with mecobalamin on the basis of the above treatment, and the patients in the combination group were treated with Bushen Tongluo Decoction on the basis of the mecobalamin group. Limb numbness and tingling, extremity paresthesia, waist and knee soreness, low qi laziness score, Toronto clinical scoring system(TCSS) score, vibration sensory threshold(VPT), lower limb nerve conduction velocity were compared. Results After treatment, the mecobalamin group and the combination treatment group had numbness and tingling, limb paraesthesia, waist and knee soreness, low qi and laziness score, TCSS score, and VPT were reduced compared with those before treatment, and the combined treatment group were lower than the mecobalamin group, the difference was statistically significant(P<0.05);after treatment, the conduction velocity of the tibial nerve, common peroneal nerve,superficial peroneal nerve, and sural nerve in the mecobalamin group and the combined group increased compared with those before treatment, and the combined group was higher than the mecobalamin group, the difference was statistically significant(P<0.05).Conclusion Self-made Bupi Yishen Tongluo Decoction combined with mecobalamin can improve the numbness and tingling of patients with diabetic collateral disease by inhibiting
作者
刘卫娟
李蕊
LIU Wei-Juan;LI Rui(Department of Traditional Chinese Medicine,Jinan Huaiyin People's Hospital,Jinan 250021,China;Comprehensive Ward,The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110014,China)
出处
《中国药物经济学》
2022年第1期75-78,82,共5页
China Journal of Pharmaceutical Economics
关键词
糖尿病
络病
补脾益肾通络
甲钴胺
周围神经病变
Diabetes
Collateral disease
Tonifying the spleen and kidney and dredging collaterals
Mecobalamin
Peripheral neuropathy
