摘要
目的探索京津冀地区成人静脉FPG水平与估算肾小球滤过率(estimated glomerular filtration rate,eGFR)的关系,进而为慢性肾脏病(chronic kidney disease,CKD)的早期发现和干预提供科学依据。方法收集京津冀地区成人自然人群的人口学特征信息、现病史、行为和生活方式,并采集空腹静脉血液检测GLU、血脂和肾功能。用CKD流行病学合作研究公式(chronic kindey disease epidemiology collaboration,CKD-EPI)估算每个受试者的eGFR,采用多重线性回归分析模型分析FPG水平和eGFR的关系。结果共分析9446人,在多重线性回归分析模型中,控制人口学特征和行为习惯及慢性病史等因素对eGFR的影响后,FBG和Log(eGFR)呈负相关(β=-0.002,P<0.001)。结论静脉FPG水平与eGFR呈线性相关,FPG的增高与eGFR下降的风险相关。
Objective To explore the relationship between venous fasting plasma glucose(FPG) and estimated glomerular filtration rate(eGFR) among adults in Beijing-Tianjin-Hebei Region, to provide a scientific basis for the early detection and intervention of chronic kidney disease(CKD). Methods The demographic characteristics, medical history, behavior and lifestyle of adult attendees at physical examination center were collected, and fasting venous blood samples were collected to detect blood glucose, blood lipids and renal function. The eGFR of each subject was estimated by chronic kindey disease epidemiology collaboration(CKD-EPI) equation. The relationship between FBG level and eGFR was analyzed by multiple linear regression. Results A total of 9 446 people were analyzed. After controlling the effects of demographic characteristics, behavior habits and chronic medical history on eGFR in the multiple linear regression model, there was a negative correlation between FBG and Log(eGFR)(β=-0.002, P<0.001). Conclusion There is a linear correlation between venous FBG and eGFR, high FBG increases the odds of decreased eGFR.
作者
刘睿浩
汪玉雪
范雅琪
贺江珊
郭佩
王建雄
李春君
张莉
张勉之
张敏英
LIU Rui-hao;WANG Yu-xue;FAN Ya-qi;HE Jiang-shan;GUO Pei;WANG Jian-xiong;LI Chun-jun;ZHANG Li;ZHANG Mian-zhi;ZHANG Min-ying(The Graduate School,Tianjin Medical University,Tianjin 300070,China;School of Medicine,Nankai University,Tianjin 300071,China;Physical Examinational Center,Tianjin Union Medical Center,Tianjin 300121,China;Physical Examinational Center,Tianjin First Central Hospital,Tianjin 300122,China;First Department of Nephropathy,Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2022年第2期131-135,共5页
Chinese Journal of Disease Control & Prevention
基金
国家重点研发计划(2016YFC0900600,2016YFC0900604)。
关键词
空腹血糖
肾小球滤过率
肾功能损伤
Fasting blood glucose
Glomerular filtration rate
Renal function injury
