摘要
目的探讨2型糖尿病患者(T2DM)中血清脂蛋白(a)[Lp(a)]水平、三酰甘油与高密度脂蛋白胆固醇比值(TG/HDL-C)与糖尿病视网膜病变(DR)的相关性。方法选取T2DM患者420例,分为无DR组(NDR)179例,非增殖期DR组(NPDR)143例,增殖期DR组(PDR)98例,比较3组患者血清Lp(a)水平和TG/HDL-C的差异,并采用Logistic回归分析血清Lp(a)水平、TG/HDL-C与DR的关系。结果与NDR组相比,NPDR和PDR组血清Lp(a)水平及TG/HDL-C均升高,且PDR组血清Lp(a)水平和TG/HDL-C均高于NPDR组,差异均有统计学意义(P<0.05);Logistic回归分析提示,血清Lp(a)水平和TG/HDL-C均是DR发生的独立危险因素;ROC曲线分析发现,血清Lp(a)水平和TG/HDL-C两者联合可更好地预测T2DM患者发生DR的风险。结论在T2DM患者中,血清Lp(a)水平和TG/HDL-C与DR密切相关。
Objective To investigate the association of diabetic retinopathy(DR)with serum lipoprotein(a)level and triglyceride/high-density lipoprotein cholesterol(TG/HDL-C)in patients with type 2 diabetes(T2DM).Methods A total of 420 patients with T2DM were divided into patients without DR(NDR,n=192),patients with non-proliferative DR(NPDR,n=143)and patients with proliferative DR(PDR,n=98).The difference of serum Lp(a)levels and TG/HDL-C among the three groups were compared,and the association of DR with serum lipoprotein(a)level and TG/HDL-C was analyzed by Logistic regression.Results Compared with NDR group,patients in NPDR group and PDR group had higher serum Lp(a)levels and TG/HDL-C.Patients in the PDR group had higher serum Lp(a)level and TG/HDL-C than that in the NPDR group,with the difference statistically significant(P<0.05).Logistic regression analysis showed that serum Lp(a)level and TG/HDL-C were independent risk factors for DR.According to the analysis of ROC curves,the combination of serum Lp(a)level and TG/HDL-C may better predict the risk of DR in patients with T2DM.Conclusion Serum Lp(a)level and TG/HDL-C were significantly correlated with DR in patients with T2DM.
作者
胡邵宁
朱书渊
魏燕斌
HU Shao-ning;ZHU Shu-yuan;WEI Yan-bin(Department of Geriatrics,Lishui Second People's Hospital,Lishui,Zhejiang 323000,China)
出处
《中国卫生检验杂志》
CAS
2022年第2期205-208,共4页
Chinese Journal of Health Laboratory Technology
