摘要
胶质瘤是颅内最常见的原发性恶性肿瘤,具有高度异质性,即使组织学分级相同,有时预后也具有显著差异,而基因分型则可以从本质上更好地阐述肿瘤的生物学行为,其中O^(6)-甲基鸟嘌呤甲基转移酶(O^(6)-methylguanine-DNA methyltransferase,MGMT)与高级别脑胶质瘤(high-grade glioma,HGGs)的预后和治疗决策紧密相关。它是一种关键的DNA修复酶,不仅与脑胶质瘤的发生发展相关,还与烷化剂化疗的敏感性以及放疗反应相关。而MGMT启动子甲基化会沉默MGMT的转录表达,是MGMT表达减少的重要机制。近年来随着科学技术的飞速进步,放射学也逐渐向人工智能的方向发展,本文对智能影像对高级别脑胶质瘤MGMT启动子甲基化状态的预测性能进行了综述。
Glioma is the most common primary malignant tumors in the brain.which is highly heterogeneous.Even if the classification is the same,sometimes the prognosis is significantly different.Genotyping can better explain the biological behavior of the tumor.Amongthem,O^(6)-methylguanine-DNA methyltransferase(MGMT)is closely related to the prognosis and treatment decisions of high-grade gliomas.It is an important DNA repair enzyme,which is not only associated with the development of glioma,but also with the sensitivity of alkylating agent chemotherapy and radiotherapy response.The methylation of the MGMT promoter will silence the transcriptional expression of MGMT,and is an important mechanism for the decrease of MGMT expression.In recent years,with the rapid advancement of science and technology,radiology has gradually developed towards the direction of artificial intelligence.The predictive performance of intelligent imaging on the methylation status of the MGMT promoter in high-grade gliomas was reviewed in this article.
作者
赵慧敏
张辉
ZHAO Huimin;ZHANG Hui(College of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China;Department of Radiology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第2期130-132,136,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(81971593、U21A20386)。
