摘要
目的:探讨血浆B型脑钠肽前体(NT-proBNP)、D-二聚体水平与急性大动脉粥样硬化前循环脑梗死(ACCI)患者脑损伤程度的相关性。方法:根据美国国立卫生研究院卒中量表(NIHSS)评分,将108例ACCI患者分为重度脑损伤(H)组(n=41)、中度脑损伤(M)组(n=37)及轻度脑损伤(L)组(n=30);另取同期行健康检查的30名体检者为对照组。采集ACCI患者入院即刻,治疗后3、7、15 d及出院时空腹静脉血检测血浆NT-proBNP及D-二聚体水平,行NIHSS及改良Rankin量表(mRS)评分,分析血浆NT-proBNP及D-二聚体水平与ACCI患者脑损伤相关性,并用ROC曲线分析预后评价能力。结果:治疗前血浆NT-proBNP、D-二聚体水平在H、M、L组组间及与对照组比较,差异均有统计学意义(P<0.05);治疗后,ACCI患者血浆NT-proBNP及D-二聚体水平及NIHSS评分、mRS评分均随治疗时间增加逐渐降低(P<0.05);血浆NT-proBNP及D-二聚体水平与NIHSS评分的相关性参数:入院即刻为(r=0.49,P<0.001),(r=0.53,P<0.001);出院时为(r=0.54,P<0.001),(r=0.43,P<0.001);与mRS评分的相关性参数分别为(r=0.37,P=0.01),(r=0.41,P<0.001);血浆NT-proBNP评估ACCI患者预后AUC=0.73,特异度0.66,敏感度0.75;D-二聚体AUC=0.71,特异度0.75,敏感度0.62。结论:血浆NT-proBNP及D-二聚体水平与ACCI患者脑损伤程度存在正相关性,且二者对患者预后情况具有较好的评估价值。
Objective:To investigate the correlation of Plasma b-type brain natriuretic peptide precursor(NT-proBNP)and D-dimer levels with brain injury degree in patients with acute pre-atherosclerotic cyclic cerebral infarction(ACCI).Methods:108 ACCI patients were selected as the research objects.According to the National Institutes of Health Stroke Scale(NIHSS)scores after admission,patients were divided into severe brain injury(H)group(41 cases),moderate brain injury(M)group(37 cases)and mild brain injury(L)group(30 cases),another 30 physical examiners who underwent physical examination at the same time were selected as the control group.Collected ACCI patients fasting venous blood at immediately after admission,3,7,and 15 d after treatment and discharged,plasma NT-proBNP and D-dimer levels were detected.Perform NIHSS and modified Rankin scale(mRS)scoring.The correlation between plasma NT-proBNP and D-dimer levels with brain injury in ACCI patients were analyzed.ROC curve was used to analyze prognostic evaluation ability.Results:Before treatment,the plasma levels of NT-proBNP and D-dimer were significantly different among the H,M,and L groups andcompared with the control group(P<0.05).After treatment,the plasma NT-proBNP and D-dimer levels,NIHSS score and mRS score of the three groups of ACCI patients gradually decreased with the increase of treatment time(P<0.05).Correlation parameters between plasma NT-proBNP and D-dimer levels and NIHSS score:immediately upon admission was(r=0.49,P<0.001),(r=0.53,P<0.001),at discharge was(r=0.54,P<0.001),(r=0.43,P<0.001).The correlation parameters with mRS scores were(r=0.37,P=0.01),(r=0.41,P<0.001).According to ROC curve analysis,the AUC of plasma NT-proBNP used to evaluate the prognosis of ACCI patients was 0.73,specificity was 0.66,sensitivity was 0.75.D-dimer AUC was 0.71,specificity was 0.75,sensitivity was 0.62.Conclusion:Plasma NT-proBNP and D-dimer levels are positively correlated with the degree of brain injury in ACCI patients,and both have good evaluation value for the prog
作者
粟显才
贝玫瑰
黄玲
王金文
吴州宁
翟志文
蒙春越
温绍锦
钟媛
SU Xian-cai;BEI Mei-gui;HUANG Ling;WANG Jin-wen;WU Zhou-ning;ZHAI Zhi-wen;MENG Chun-yue;WEN Shao-jin;ZHONG Yuan(Depantment of Internal Medicine,Liuzhou Red Cross Hospital,Liuzhou 545001,Guangxi,China;Department of Ultrasound,Liuzhou Red Cross Hospital,Liuzhou 545001,Guangxi,China;Department of Emergency,Liuzhou Red Cross Hospital,Liuzhou 545001,Guangxi,China;Department of Physical Examination,Liuzhou Red Cross Hospital,Liuzhou 545001,Guangxi,China)
出处
《川北医学院学报》
CAS
2022年第2期182-186,共5页
Journal of North Sichuan Medical College
基金
广西壮族自治区卫生健康委员会自筹经费科研项目(Z20210982)。
