摘要
猪流行性腹泻(Porcine epidemic diarrhea,PED)是由猪流行性腹泻病毒(PED virus,PEDV)引起的一种严重危害养猪生产的常见疫病。近年来,由于新的PEDV变异毒株的出现,许多国家的养猪业遭受了巨大的经济损失。PEDV也因此受到更多关注,关于PEDV的研究报道也日渐增多。基于国内外有关PEDV的最新研究进展,本文系统归纳和分析了PEDV结构蛋白和非结构蛋白单克隆抗体以及单克隆抗体识别的特异性抗原表位,以期为开发鉴别诊断方法和表位疫苗等提供信息。
Porcine epidemic diarrhea(PED),caused by porcine epidemic diarrhea virus(PEDV),is a common disease that seriously damage the pig production.In recent years,lots of country’s pig industry suffered huge economic losses due to the newly emerged PEDV variation strains.Consequently,PEDV caught more attention,and researches and reports about PEDV increased significantly.Based on the recent research progress about PEDV both in our country and abroad,this paper systematically summarized and analyzed monoclonal antibodies of PEDV structural proteins and non-structural proteins and its specific antigenic epitopes in order to provide information for developing differential diagnostic methods and epitope-based vaccines.
作者
张志榜
彭维祺
ZHANG Zhibang;PENG Weiqi(College of Life Science and Resource Environment,Yichun University,Yichun 336000,China;Tropical Crops Genetic Resources Institute,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2022年第1期235-245,共11页
Chinese Journal of Virology
基金
江西省教育厅科学技术研究项目(项目号:GJJ190844),题目:猪繁殖与呼吸综合征病毒感染性克隆的构建及初步应用
海南省自然科学基金青年基金项目(项目号:319QN311),题目:冠状病毒核酸外切酶对猪繁殖与呼吸综合征病毒复制保真性的影响。
关键词
猪流行性腹泻病毒
单克隆抗体
抗原表位
Porcine epidemic diarrhea virus
Monoclonal antibody
Antigenic epitope
