摘要
上呼吸道与外界环境直接相通,天然免疫系统是其抵抗病原体感染的第一道防线。在抗病毒感染中,干扰素(interferon,IFN)是抗病毒天然免疫系统的主要成分,IFN-λ是新近发现的主要产生于黏膜屏障的免疫效应分子,其主要通过酪氨酸激酶(Janus kinase,JAK)信号转导和转录激活因子(signal transducer and activator of transcription,STAT)信号通路发挥生物学作用,在调节呼吸道黏膜先天免疫和后天获得性免疫中发挥重要作用。IFN-λ优先在黏膜屏障上表达,发挥持久的抗病毒效应,控制免疫炎症损伤,正成为上呼吸道抗病毒免疫研究的新焦点,尤其在抗击新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)方面具有较好的前景。本文主要对IFN-λ在上呼吸道抗病毒免疫中的研究进展进行总结,为上呼吸道病毒感染的预防和治疗提供新思路。
Upper respiratory tract is directly connected with the external environment,and its natural immune system is the first line of defense against pathogens. In antiviral infection,interferon(IFN)is the main component of the antiviral natural immune system and IFN-λ is a newly discovered immune effector molecule that is mainly produced in the mucosal barrier. IFN-λ exerts a biological role through Janus kinase(JAK)and signal transducer and activator of transcription(STAT)signaling pathway,and plays an important part in regulating innate and acquired immunity of respiratory mucosa. IFN-λ principally expresses on the mucosal barrier with a long-lasting antiviral impact and controls immuneinflammatory damage,which is becoming a new focus of antiviral immunity research in the upper respiratory tract,especially in fighting against2019 novel coronavirus diseases(COVID-19). Thus,we summarize the research progress of IFN-λ antiviral immunity in the upper respiratory tract to provide new insight in the prevention and treatment of viral infection in the upper respiratory tract.
作者
范君言
李子帅
刘文斌
曹广文
FAN Junyan;LI Zishuai;LIU Wenbin;CAO Guangwen(Department of Epidemiology,Navy Medical University,Shanghai 200433,China)
出处
《上海预防医学》
CAS
2022年第1期87-91,共5页
Shanghai Journal of Preventive Medicine
基金
国家自然科学基金(82041022)
上海市科学技术委员会项目(20JC1410200,20431900404)。
