摘要
内脏型肥胖2型糖尿病(T2DM)患者可能发生外周动脉疾病(PAD)等并发症。PAD起病隐匿,诊断缺乏灵敏性,确诊时或已出现不可逆血管损伤,继而使患者致残、致死。氧化应激、炎症反应及内皮功能障碍等是T2DM并发PAD的关键危险因素;内脏型肥胖通过持续加剧内皮功能障碍和血管氧化应激等机制,引起动脉粥样硬化而导致或加重PAD。利用多靶点早期预防及干预内脏型肥胖T2DM患者PAD的发生、发展,对提高患者生活质量,减少病亡率具有重要临床意义。
Patients with visceral obesity type 2 diabetes mellitus(T2DM)may have complications such as peripheral artery disease(PAD).The onset of PAD is hidden,the diagnosis is lack of sensitivity,and irreversible vascular injury may have occurred at the time of diagnosis,which leads to disability and death of the patient.Oxidative stress,inflammatory reaction and endothelial dysfunction are the key risk factors of T2DM complicated with PAD.Visceral obesity causes atherosclerosis and aggravates PAD by continuously aggravating endothelial dysfunction and vascular oxidative stress.Therefore,the use of multi-target early prevention and intervention of visceral obesity T2DM patients with the occurrence and development of PAD,to improve the quality of life of patients,reduce the incidence of the disease has important clinical significance.
作者
卢新妍(综述)
林萱
崔静(审校)
LU Xin-yan;LING Xuan;CUI Jing(Medical College of Wuhan University of Science and Technology, Wuhan 430081,China;Department of Endocrinology, CR & WISCO General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430080, China)
出处
《微循环学杂志》
2022年第1期71-75,共5页
Chinese Journal of Microcirculation
基金
湖北省微循环学会人才培养专项科研基金(HBWXH2018(1)-6)。
关键词
内脏型肥胖
2型糖尿病
外周动脉疾病
Visceral obesity
Type 2 diabetes mellitus
Peripheral artery disease
