摘要
目的:探讨激素联合雷公藤治疗抗PLA2R抗体阳性中老年特发性膜性肾病(IMN)效果及对抗PLA2R抗体滴度的影响。方法:选取2019年1月~2021年6月我院收治的26例IMN的45岁以上的中老年患者,且检测血清抗PLA2R抗体阳性。依照随机数字表法将其分为观察组(13例)与对照组(13例),分别于入院时、用药12周、用药24周完善化验与检查,并对相关数据进行统计与分析。结果:用药12周时,两组患者间生化指标、临床完全缓解率均无统计学差异(P>0.05)。用药24周时,观察组的血浆白蛋白水平高于对照组,差异均有统计学意义(P<0.05);24小时尿蛋白定量、血清抗PLA2R抗体浓度均低于对照组,差异同样具有统计学意义(P<0.05);临床完全缓解率高于对照组,差异同样具有统计学意义(P<0.05)。结论:激素联合雷公藤多甙对血清抗PLA2R抗体阳性的中老年IMN安全且有效,能有效增加患者临床缓解率。
Objective:To investigate the effect of hormone combined with Tripterygium Wilfordii on the treatment of middle-aged idiopathic membranous nephropathy(IMN)with anti-PLA2R positive.Methods:Atotalof26 patients over 45 years old with IMN treated in our hospital from January 2019 to June 2021 were selectedandrandomly divided into observation group(13 cases)and control group(13 cases).Their serum anti-PLA2R was positive.The tests and examinations were completed at admission,12 weeks and 24 weeks.The relevant data were counted and analyzed.Results:After 12 weeks treatment,there was no significant difference in biochemical indexes and clinical complete remission rate between the two groups(P>0.05).However,after 24 weeks treatment,the plasma albumin level in the observation group was higher than that in the control group(P<0.05),while 24-hour urinary protein and serum anti-PLA2R concentration were lower than those in the control group(P<0.05).The clinical complete remission rate was higher than that in the control group with statistically significant(P<0.05).Conclusion:Hormone combined with Tripterygium wilfordii is safe and effective for middle-aged IMN with serum anti-PLA2R positive.It could effectively increase the clinical remission rate of patients.
作者
谢敏娟
徐石张
XIE Min-juan;XU Shi-zhang(Medical College of Yichun University,Yichun 336000,China;Department of Nephrology,The People’s Hospital of Yichun City,Yichun 336000,China)
出处
《宜春学院学报》
2021年第12期26-29,共4页
Journal of Yichun University
基金
江西省卫生健康委员会科技计划项目(编号:20204732)。
关键词
激素
雷公藤
抗PLA2R抗体
中老年
IMN
疗效
hormones
Tripterygium wilfordii
anti-PLA2R
middle aged
IMN
curative effect
