摘要
Machine learning models may outperform traditional statistical regression algorithms for predicting clinical outcomes.Proper validation of building such models and tuning their underlying algorithms is necessary to avoid over-fitting and poor generalizability,which smaller datasets can be more prone to.In an effort to educate readers interested in artificial intelligence and model-building based on machine-learning algorithms,we outline important details on crossvalidation techniques that can enhance the performance and generalizability of such models.